Increased Trinucleotide Repeat Instability with Advanced Maternal Age (original) (raw)

Journal Article

,

1

Institute of Human Genetics, University of Minnesota

,

Minneapolis, MN 55455, USA

2

Department of Laboratory Medicine and Pathology, University of Minnesota

,

Minneapolis, MN 55455, USA

Search for other works by this author on:

,

1

Institute of Human Genetics, University of Minnesota

,

Minneapolis, MN 55455, USA

2

Department of Laboratory Medicine and Pathology, University of Minnesota

,

Minneapolis, MN 55455, USA

Search for other works by this author on:

,

2

Department of Laboratory Medicine and Pathology, University of Minnesota

,

Minneapolis, MN 55455, USA

Search for other works by this author on:

,

4

Departments of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine

,

Houston, TX 77030, USA

5

Howard Hughes Medical Institute, Baylor College of Medicine

,

Houston, TX 77030, USA

Search for other works by this author on:

1

Institute of Human Genetics, University of Minnesota

,

Minneapolis, MN 55455, USA

2

Department of Laboratory Medicine and Pathology, University of Minnesota

,

Minneapolis, MN 55455, USA

3

Department of Biochemistry, University of Minnesota

,

Minneapolis, MN 55455, USA

* To whom correspondence should be addressed. Tel: +1 612 625 3647; Fax: +1 612 626 2600; Email: harry@lenti.med.umn.edu

Search for other works by this author on:

Published:

01 November 1997

• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Michael D. Kaytor, Eric N. Burright, Lisa A. Duvick, Huda Y. Zoghbi, Harry T. Orr, Increased Trinucleotide Repeat Instability with Advanced Maternal Age, Human Molecular Genetics, Volume 6, Issue 12, November 1997, Pages 2135–2139, https://doi.org/10.1093/hmg/6.12.2135
Close

Navbar Search Filter Mobile Enter search term Search

Abstract

Nucleotide repeat instability is associated with an increasing number of cancers and neurological disorders. The mechanisms that govern repeat instability in these biological disorders are not well understood. To examine genetic aspects of repeat instability we have introduced an expanded CAG trinucleotide repeat into transgenic mice. We have detected intergenerational CAG repeat instability in transgenic mice only when the transgene was maternally transmitted. These intergenerational instabilities increased in frequency and magnitude as the transgenic mother aged. Furthermore, triplet repeat variations were detected in unfertilized oocytes and were comparable with those in the offspring. These data show that maternal repeat instability in the transgenic mice occurs after meiotic DNA replication and prior to oocyte fertilization. Thus, these findings demonstrate that advanced maternal age is an important factor for instability of nucleotide repeats in mammalian DNA.

© 1997 Oxford University Press

Topic:

• nervous system disorders
• animals, transgenic
• cancer
• dna
• dna replication
• fertilization
• mammals
• mice, transgenic
• mothers
• nucleotides
• oocytes
• transgenes
• trinucleotide repeats
• genetic aspects
• spinocerebellar ataxia type 1
• pregnancy with advanced maternal age
• offspring

You do not currently have access to this article.

Personal account

• Sign in with email/username & password
• Get email alerts
• Save searches
• Purchase content
• Activate your purchase/trial code
• Add your ORCID iD

Get help with access

Institutional access

Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:

IP based access

Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

Sign in through your institution

Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.

1. Click Sign in through your institution.
2. Select your institution from the list provided, which will take you to your institution's website to sign in.
3. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
4. Following successful sign in, you will be returned to Oxford Academic.

If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.

Sign in with a library card

Enter your library card number to sign in. If you cannot sign in, please contact your librarian.

Society Members

Society member access to a journal is achieved in one of the following ways:

Sign in through society site

Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:

1. Click Sign in through society site.
2. When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
3. Following successful sign in, you will be returned to Oxford Academic.

If you do not have a society account or have forgotten your username or password, please contact your society.

Sign in using a personal account

Some societies use Oxford Academic personal accounts to provide access to their members. See below.

Personal account

A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.

Some societies use Oxford Academic personal accounts to provide access to their members.

Viewing your signed in accounts

Click the account icon in the top right to:

• View your signed in personal account and access account management features.
• View the institutional accounts that are providing access.

Signed in but can't access content

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.

Institutional account management

For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Purchase

Short-term Access

To purchase short-term access, please sign in to your personal account above.

Don't already have a personal account? Register

Increased Trinucleotide Repeat Instability with Advanced Maternal Age - 24 Hours access

EUR €38.00

GBP £33.00

USD $41.00

Rental

This article is also available for rental through DeepDyve.

Advertisement intended for healthcare professionals

Citations

Views

Altmetric

Metrics

Total Views 863

593 Pageviews

270 PDF Downloads

Since 1/1/2017

Citations

81 Web of Science

×

Email alerts

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic

Advertisement intended for healthcare professionals