Body Size and Risk of Colon and Rectal Cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC) (original) (raw)

Journal Article

,

Affiliations of authors: Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany (TP, PHL, HB, MMB); Division of Population Health and Information, Alberta Cancer Board, Calgary, Alberta, Canada (CF); International Agency for Research on Cancer, Lyon, France (TN, PF, RK, NS, ER); Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark (A. Tjønneland, JH); Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark (KO); INSERM U 521, Institut Gustave Roussy, Villejuif, France (FCC, MCBR, GG); Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany (JL, NB); Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Athens, Greece (A. Trichopoulou, DT); Epidemiology Unit, National Cancer Institute, Milan, Italy (SS); Molecular and Nutritional Epidemiology Unit, CSPO-Scientific Institute of Tuscany, Florence, Italy (DP); Cancer Registry, Azienda Ospedaliera “Civile M.P. Arezzo,” Ragusa, Italy (RT); Imperial College London, UK, and University of Torino, Turin, Italy (PV); Dipartimento di Medicina Clinica e Sperimentale, Università di Napoli, Naples, Italy (SP); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands (PHMP); Center for Nutrition and Health (HBBdM), Center for Information Technology and Informatics (HCB), National Institute of Public Health and the Environment, Bilthoven, The Netherlands; Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden (BVG, RP); Department of Medicine, Lund University, Malmö, Sweden (GB); Department of Epidemiology, Catalan Institute of Oncology, IDIBELL, Barcelona, Spain (CAG); Department of Public Health of Guipuzkoa, San Sebastian, Spain (MD); Public Health Institute of Navarra, Pamplona, Spain (AB); Epidemiology Department, Murcia Health Council, Murcia, Spain (CN); Escuela Andaluza de Salud Publica, Granada, Spain (CM); Health Information Unit, Public Health and Health Planning Directorate, Asturias, Spain (JRQ); Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, UK (AR, NA); Dunn Human Nutrition Unit, Medical Research Council, Cambridge, UK (SB); Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK (KTK)

Correspondence to: Tobias Pischon, MD, MPH, Department of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114–116, 14558 Nuthetal, Germany (e-mail: pischon@mail.dife.de ).

Search for other works by this author on:

,

Affiliations of authors: Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany (TP, PHL, HB, MMB); Division of Population Health and Information, Alberta Cancer Board, Calgary, Alberta, Canada (CF); International Agency for Research on Cancer, Lyon, France (TN, PF, RK, NS, ER); Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark (A. Tjønneland, JH); Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark (KO); INSERM U 521, Institut Gustave Roussy, Villejuif, France (FCC, MCBR, GG); Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany (JL, NB); Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Athens, Greece (A. Trichopoulou, DT); Epidemiology Unit, National Cancer Institute, Milan, Italy (SS); Molecular and Nutritional Epidemiology Unit, CSPO-Scientific Institute of Tuscany, Florence, Italy (DP); Cancer Registry, Azienda Ospedaliera “Civile M.P. Arezzo,” Ragusa, Italy (RT); Imperial College London, UK, and University of Torino, Turin, Italy (PV); Dipartimento di Medicina Clinica e Sperimentale, Università di Napoli, Naples, Italy (SP); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands (PHMP); Center for Nutrition and Health (HBBdM), Center for Information Technology and Informatics (HCB), National Institute of Public Health and the Environment, Bilthoven, The Netherlands; Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden (BVG, RP); Department of Medicine, Lund University, Malmö, Sweden (GB); Department of Epidemiology, Catalan Institute of Oncology, IDIBELL, Barcelona, Spain (CAG); Department of Public Health of Guipuzkoa, San Sebastian, Spain (MD); Public Health Institute of Navarra, Pamplona, Spain (AB); Epidemiology Department, Murcia Health Council, Murcia, Spain (CN); Escuela Andaluza de Salud Publica, Granada, Spain (CM); Health Information Unit, Public Health and Health Planning Directorate, Asturias, Spain (JRQ); Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, UK (AR, NA); Dunn Human Nutrition Unit, Medical Research Council, Cambridge, UK (SB); Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK (KTK)

Search for other works by this author on:

,

Affiliations of authors: Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany (TP, PHL, HB, MMB); Division of Population Health and Information, Alberta Cancer Board, Calgary, Alberta, Canada (CF); International Agency for Research on Cancer, Lyon, France (TN, PF, RK, NS, ER); Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark (A. Tjønneland, JH); Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark (KO); INSERM U 521, Institut Gustave Roussy, Villejuif, France (FCC, MCBR, GG); Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany (JL, NB); Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Athens, Greece (A. Trichopoulou, DT); Epidemiology Unit, National Cancer Institute, Milan, Italy (SS); Molecular and Nutritional Epidemiology Unit, CSPO-Scientific Institute of Tuscany, Florence, Italy (DP); Cancer Registry, Azienda Ospedaliera “Civile M.P. Arezzo,” Ragusa, Italy (RT); Imperial College London, UK, and University of Torino, Turin, Italy (PV); Dipartimento di Medicina Clinica e Sperimentale, Università di Napoli, Naples, Italy (SP); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands (PHMP); Center for Nutrition and Health (HBBdM), Center for Information Technology and Informatics (HCB), National Institute of Public Health and the Environment, Bilthoven, The Netherlands; Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden (BVG, RP); Department of Medicine, Lund University, Malmö, Sweden (GB); Department of Epidemiology, Catalan Institute of Oncology, IDIBELL, Barcelona, Spain (CAG); Department of Public Health of Guipuzkoa, San Sebastian, Spain (MD); Public Health Institute of Navarra, Pamplona, Spain (AB); Epidemiology Department, Murcia Health Council, Murcia, Spain (CN); Escuela Andaluza de Salud Publica, Granada, Spain (CM); Health Information Unit, Public Health and Health Planning Directorate, Asturias, Spain (JRQ); Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, UK (AR, NA); Dunn Human Nutrition Unit, Medical Research Council, Cambridge, UK (SB); Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK (KTK)

Search for other works by this author on:

,

Affiliations of authors: Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany (TP, PHL, HB, MMB); Division of Population Health and Information, Alberta Cancer Board, Calgary, Alberta, Canada (CF); International Agency for Research on Cancer, Lyon, France (TN, PF, RK, NS, ER); Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark (A. Tjønneland, JH); Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark (KO); INSERM U 521, Institut Gustave Roussy, Villejuif, France (FCC, MCBR, GG); Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany (JL, NB); Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Athens, Greece (A. Trichopoulou, DT); Epidemiology Unit, National Cancer Institute, Milan, Italy (SS); Molecular and Nutritional Epidemiology Unit, CSPO-Scientific Institute of Tuscany, Florence, Italy (DP); Cancer Registry, Azienda Ospedaliera “Civile M.P. Arezzo,” Ragusa, Italy (RT); Imperial College London, UK, and University of Torino, Turin, Italy (PV); Dipartimento di Medicina Clinica e Sperimentale, Università di Napoli, Naples, Italy (SP); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands (PHMP); Center for Nutrition and Health (HBBdM), Center for Information Technology and Informatics (HCB), National Institute of Public Health and the Environment, Bilthoven, The Netherlands; Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden (BVG, RP); Department of Medicine, Lund University, Malmö, Sweden (GB); Department of Epidemiology, Catalan Institute of Oncology, IDIBELL, Barcelona, Spain (CAG); Department of Public Health of Guipuzkoa, San Sebastian, Spain (MD); Public Health Institute of Navarra, Pamplona, Spain (AB); Epidemiology Department, Murcia Health Council, Murcia, Spain (CN); Escuela Andaluza de Salud Publica, Granada, Spain (CM); Health Information Unit, Public Health and Health Planning Directorate, Asturias, Spain (JRQ); Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, UK (AR, NA); Dunn Human Nutrition Unit, Medical Research Council, Cambridge, UK (SB); Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK (KTK)

Search for other works by this author on:

,

Affiliations of authors: Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany (TP, PHL, HB, MMB); Division of Population Health and Information, Alberta Cancer Board, Calgary, Alberta, Canada (CF); International Agency for Research on Cancer, Lyon, France (TN, PF, RK, NS, ER); Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark (A. Tjønneland, JH); Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark (KO); INSERM U 521, Institut Gustave Roussy, Villejuif, France (FCC, MCBR, GG); Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany (JL, NB); Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Athens, Greece (A. Trichopoulou, DT); Epidemiology Unit, National Cancer Institute, Milan, Italy (SS); Molecular and Nutritional Epidemiology Unit, CSPO-Scientific Institute of Tuscany, Florence, Italy (DP); Cancer Registry, Azienda Ospedaliera “Civile M.P. Arezzo,” Ragusa, Italy (RT); Imperial College London, UK, and University of Torino, Turin, Italy (PV); Dipartimento di Medicina Clinica e Sperimentale, Università di Napoli, Naples, Italy (SP); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands (PHMP); Center for Nutrition and Health (HBBdM), Center for Information Technology and Informatics (HCB), National Institute of Public Health and the Environment, Bilthoven, The Netherlands; Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden (BVG, RP); Department of Medicine, Lund University, Malmö, Sweden (GB); Department of Epidemiology, Catalan Institute of Oncology, IDIBELL, Barcelona, Spain (CAG); Department of Public Health of Guipuzkoa, San Sebastian, Spain (MD); Public Health Institute of Navarra, Pamplona, Spain (AB); Epidemiology Department, Murcia Health Council, Murcia, Spain (CN); Escuela Andaluza de Salud Publica, Granada, Spain (CM); Health Information Unit, Public Health and Health Planning Directorate, Asturias, Spain (JRQ); Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, UK (AR, NA); Dunn Human Nutrition Unit, Medical Research Council, Cambridge, UK (SB); Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK (KTK)

Search for other works by this author on:

,

Affiliations of authors: Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany (TP, PHL, HB, MMB); Division of Population Health and Information, Alberta Cancer Board, Calgary, Alberta, Canada (CF); International Agency for Research on Cancer, Lyon, France (TN, PF, RK, NS, ER); Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark (A. Tjønneland, JH); Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark (KO); INSERM U 521, Institut Gustave Roussy, Villejuif, France (FCC, MCBR, GG); Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany (JL, NB); Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Athens, Greece (A. Trichopoulou, DT); Epidemiology Unit, National Cancer Institute, Milan, Italy (SS); Molecular and Nutritional Epidemiology Unit, CSPO-Scientific Institute of Tuscany, Florence, Italy (DP); Cancer Registry, Azienda Ospedaliera “Civile M.P. Arezzo,” Ragusa, Italy (RT); Imperial College London, UK, and University of Torino, Turin, Italy (PV); Dipartimento di Medicina Clinica e Sperimentale, Università di Napoli, Naples, Italy (SP); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands (PHMP); Center for Nutrition and Health (HBBdM), Center for Information Technology and Informatics (HCB), National Institute of Public Health and the Environment, Bilthoven, The Netherlands; Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden (BVG, RP); Department of Medicine, Lund University, Malmö, Sweden (GB); Department of Epidemiology, Catalan Institute of Oncology, IDIBELL, Barcelona, Spain (CAG); Department of Public Health of Guipuzkoa, San Sebastian, Spain (MD); Public Health Institute of Navarra, Pamplona, Spain (AB); Epidemiology Department, Murcia Health Council, Murcia, Spain (CN); Escuela Andaluza de Salud Publica, Granada, Spain (CM); Health Information Unit, Public Health and Health Planning Directorate, Asturias, Spain (JRQ); Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, UK (AR, NA); Dunn Human Nutrition Unit, Medical Research Council, Cambridge, UK (SB); Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK (KTK)

Search for other works by this author on:

,

Affiliations of authors: Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany (TP, PHL, HB, MMB); Division of Population Health and Information, Alberta Cancer Board, Calgary, Alberta, Canada (CF); International Agency for Research on Cancer, Lyon, France (TN, PF, RK, NS, ER); Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark (A. Tjønneland, JH); Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark (KO); INSERM U 521, Institut Gustave Roussy, Villejuif, France (FCC, MCBR, GG); Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany (JL, NB); Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Athens, Greece (A. Trichopoulou, DT); Epidemiology Unit, National Cancer Institute, Milan, Italy (SS); Molecular and Nutritional Epidemiology Unit, CSPO-Scientific Institute of Tuscany, Florence, Italy (DP); Cancer Registry, Azienda Ospedaliera “Civile M.P. Arezzo,” Ragusa, Italy (RT); Imperial College London, UK, and University of Torino, Turin, Italy (PV); Dipartimento di Medicina Clinica e Sperimentale, Università di Napoli, Naples, Italy (SP); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands (PHMP); Center for Nutrition and Health (HBBdM), Center for Information Technology and Informatics (HCB), National Institute of Public Health and the Environment, Bilthoven, The Netherlands; Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden (BVG, RP); Department of Medicine, Lund University, Malmö, Sweden (GB); Department of Epidemiology, Catalan Institute of Oncology, IDIBELL, Barcelona, Spain (CAG); Department of Public Health of Guipuzkoa, San Sebastian, Spain (MD); Public Health Institute of Navarra, Pamplona, Spain (AB); Epidemiology Department, Murcia Health Council, Murcia, Spain (CN); Escuela Andaluza de Salud Publica, Granada, Spain (CM); Health Information Unit, Public Health and Health Planning Directorate, Asturias, Spain (JRQ); Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, UK (AR, NA); Dunn Human Nutrition Unit, Medical Research Council, Cambridge, UK (SB); Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK (KTK)

Search for other works by this author on:

,

Affiliations of authors: Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany (TP, PHL, HB, MMB); Division of Population Health and Information, Alberta Cancer Board, Calgary, Alberta, Canada (CF); International Agency for Research on Cancer, Lyon, France (TN, PF, RK, NS, ER); Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark (A. Tjønneland, JH); Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark (KO); INSERM U 521, Institut Gustave Roussy, Villejuif, France (FCC, MCBR, GG); Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany (JL, NB); Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Athens, Greece (A. Trichopoulou, DT); Epidemiology Unit, National Cancer Institute, Milan, Italy (SS); Molecular and Nutritional Epidemiology Unit, CSPO-Scientific Institute of Tuscany, Florence, Italy (DP); Cancer Registry, Azienda Ospedaliera “Civile M.P. Arezzo,” Ragusa, Italy (RT); Imperial College London, UK, and University of Torino, Turin, Italy (PV); Dipartimento di Medicina Clinica e Sperimentale, Università di Napoli, Naples, Italy (SP); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands (PHMP); Center for Nutrition and Health (HBBdM), Center for Information Technology and Informatics (HCB), National Institute of Public Health and the Environment, Bilthoven, The Netherlands; Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden (BVG, RP); Department of Medicine, Lund University, Malmö, Sweden (GB); Department of Epidemiology, Catalan Institute of Oncology, IDIBELL, Barcelona, Spain (CAG); Department of Public Health of Guipuzkoa, San Sebastian, Spain (MD); Public Health Institute of Navarra, Pamplona, Spain (AB); Epidemiology Department, Murcia Health Council, Murcia, Spain (CN); Escuela Andaluza de Salud Publica, Granada, Spain (CM); Health Information Unit, Public Health and Health Planning Directorate, Asturias, Spain (JRQ); Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, UK (AR, NA); Dunn Human Nutrition Unit, Medical Research Council, Cambridge, UK (SB); Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK (KTK)

Search for other works by this author on:

,

Françoise Clavel-Chapelon

Affiliations of authors: Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany (TP, PHL, HB, MMB); Division of Population Health and Information, Alberta Cancer Board, Calgary, Alberta, Canada (CF); International Agency for Research on Cancer, Lyon, France (TN, PF, RK, NS, ER); Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark (A. Tjønneland, JH); Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark (KO); INSERM U 521, Institut Gustave Roussy, Villejuif, France (FCC, MCBR, GG); Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany (JL, NB); Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Athens, Greece (A. Trichopoulou, DT); Epidemiology Unit, National Cancer Institute, Milan, Italy (SS); Molecular and Nutritional Epidemiology Unit, CSPO-Scientific Institute of Tuscany, Florence, Italy (DP); Cancer Registry, Azienda Ospedaliera “Civile M.P. Arezzo,” Ragusa, Italy (RT); Imperial College London, UK, and University of Torino, Turin, Italy (PV); Dipartimento di Medicina Clinica e Sperimentale, Università di Napoli, Naples, Italy (SP); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands (PHMP); Center for Nutrition and Health (HBBdM), Center for Information Technology and Informatics (HCB), National Institute of Public Health and the Environment, Bilthoven, The Netherlands; Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden (BVG, RP); Department of Medicine, Lund University, Malmö, Sweden (GB); Department of Epidemiology, Catalan Institute of Oncology, IDIBELL, Barcelona, Spain (CAG); Department of Public Health of Guipuzkoa, San Sebastian, Spain (MD); Public Health Institute of Navarra, Pamplona, Spain (AB); Epidemiology Department, Murcia Health Council, Murcia, Spain (CN); Escuela Andaluza de Salud Publica, Granada, Spain (CM); Health Information Unit, Public Health and Health Planning Directorate, Asturias, Spain (JRQ); Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, UK (AR, NA); Dunn Human Nutrition Unit, Medical Research Council, Cambridge, UK (SB); Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK (KTK)

Search for other works by this author on:

,

Marie-Christine Boutron-Ruault

Affiliations of authors: Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany (TP, PHL, HB, MMB); Division of Population Health and Information, Alberta Cancer Board, Calgary, Alberta, Canada (CF); International Agency for Research on Cancer, Lyon, France (TN, PF, RK, NS, ER); Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark (A. Tjønneland, JH); Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark (KO); INSERM U 521, Institut Gustave Roussy, Villejuif, France (FCC, MCBR, GG); Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany (JL, NB); Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Athens, Greece (A. Trichopoulou, DT); Epidemiology Unit, National Cancer Institute, Milan, Italy (SS); Molecular and Nutritional Epidemiology Unit, CSPO-Scientific Institute of Tuscany, Florence, Italy (DP); Cancer Registry, Azienda Ospedaliera “Civile M.P. Arezzo,” Ragusa, Italy (RT); Imperial College London, UK, and University of Torino, Turin, Italy (PV); Dipartimento di Medicina Clinica e Sperimentale, Università di Napoli, Naples, Italy (SP); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands (PHMP); Center for Nutrition and Health (HBBdM), Center for Information Technology and Informatics (HCB), National Institute of Public Health and the Environment, Bilthoven, The Netherlands; Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden (BVG, RP); Department of Medicine, Lund University, Malmö, Sweden (GB); Department of Epidemiology, Catalan Institute of Oncology, IDIBELL, Barcelona, Spain (CAG); Department of Public Health of Guipuzkoa, San Sebastian, Spain (MD); Public Health Institute of Navarra, Pamplona, Spain (AB); Epidemiology Department, Murcia Health Council, Murcia, Spain (CN); Escuela Andaluza de Salud Publica, Granada, Spain (CM); Health Information Unit, Public Health and Health Planning Directorate, Asturias, Spain (JRQ); Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, UK (AR, NA); Dunn Human Nutrition Unit, Medical Research Council, Cambridge, UK (SB); Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK (KTK)

Search for other works by this author on:

... Show more

Received:

13 December 2005

Revision received:

18 April 2006

• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Tobias Pischon, Petra H. Lahmann, Heiner Boeing, Christine Friedenreich, Teresa Norat, Anne Tjønneland, Jytte Halkjaer, Kim Overvad, Françoise Clavel-Chapelon, Marie-Christine Boutron-Ruault, Gregory Guernec, Manuela M. Bergmann, Jakob Linseisen, Nikolaus Becker, Antonia Trichopoulou, Dimitrios Trichopoulos, Sabina Sieri, Domenico Palli, Rosario Tumino, Paolo Vineis, Salvatore Panico, Petra H. M. Peeters, H. Bas Bueno-de-Mesquita, Hendriek C. Boshuizen, Bethany Van Guelpen, Richard Palmqvist, Göran Berglund, Carlos Alberto Gonzalez, Miren Dorronsoro, Aurelio Barricarte, Carmen Navarro, Carmen Martinez, J. Ramón Quirós, Andrew Roddam, Naomi Allen, Sheila Bingham, Kay-Tee Khaw, Pietro Ferrari, Rudolf Kaaks, Nadia Slimani, Elio Riboli, Body Size and Risk of Colon and Rectal Cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC), JNCI: Journal of the National Cancer Institute, Volume 98, Issue 13, 5 July 2006, Pages 920–931, https://doi.org/10.1093/jnci/djj246
Close

Navbar Search Filter Mobile Enter search term Search

Abstract

Background: Body weight and body mass index (BMI) are positively related to risk of colon cancer in men, whereas weak or no associations exist in women. This discrepancy may be related to differences in fat distribution between sexes or to the use of hormone replacement therapy (HRT) in women. Methods: We used multivariable adjusted Cox proportional hazards models to examine the association between anthropometric measures and risks of colon and rectal cancer among 368 277 men and women who were free of cancer at baseline from nine countries of the European Prospective Investigation Into Cancer and Nutrition. All statistical tests were two-sided. Results: During 6.1 years of follow-up, we identified 984 and 586 patients with colon and rectal cancer, respectively. Body weight and BMI were statistically significantly associated with colon cancer risk in men (highest versus lowest quintile of BMI, relative risk [RR] = 1.55, 95% confidence interval [CI] = 1.12 to 2.15; _P_trend = .006) but not in women. In contrast, comparisons of the highest to the lowest quintile showed that several anthropometric measures, including waist circumference (men, RR = 1.39, 95% CI = 1.01 to 1.93; _P_trend = .001; women, RR = 1.48, 95% CI = 1.08 to 2.03; _P_trend = .008), waist-to-hip ratio (WHR; men, RR = 1.51, 95% CI = 1.06 to 2.15; _P_trend = .006; women, RR = 1.52, 95% CI = 1.12 to 2.05; _P_trend = .002), and height (men, RR = 1.40, 95% CI = 0.99 to 1.98; _P_trend = .04; women, RR = 1.79, 95% CI = 1.30 to 2.46; _P_trend <.001) were related to colon cancer risk in both sexes. The estimated absolute risk of developing colon cancer within 5 years was 203 and 131 cases per 100 000 men and 129 and 86 cases per 100 000 women in the highest and lowest quintiles of WHR, respectively. Upon further stratification, no association of waist circumference and WHR with risk of colon cancer was observed among postmenopausal women who used HRT. None of the anthropometric measures was statistically significantly related to rectal cancer. Conclusions: Waist circumference and WHR, indicators of abdominal obesity, were strongly associated with colon cancer risk in men and women in this population. The association of abdominal obesity with colon cancer risk may vary depending on HRT use in postmenopausal women; however, these findings require confirmation in future studies.

© The Author 2006. Published by Oxford University Press.

Topic:

• hormone replacement therapy
• body mass index procedure
• waist-hip ratio
• cancer
• colorectal cancer
• follow-up
• postmenopause
• colon
• colon cancer
• rectal carcinoma
• body fat distribution
• stratification
• waist circumference
• anthropometric measures
• obesity, abdominal
• nutrition in cancer

You do not currently have access to this article.

Personal account

• Sign in with email/username & password
• Get email alerts
• Save searches
• Purchase content
• Activate your purchase/trial code
• Add your ORCID iD

Get help with access

Institutional access

Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:

IP based access

Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

Sign in through your institution

Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.

1. Click Sign in through your institution.
2. Select your institution from the list provided, which will take you to your institution's website to sign in.
3. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
4. Following successful sign in, you will be returned to Oxford Academic.

If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.

Sign in with a library card

Enter your library card number to sign in. If you cannot sign in, please contact your librarian.

Society Members

Society member access to a journal is achieved in one of the following ways:

Sign in through society site

Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:

1. Click Sign in through society site.
2. When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
3. Following successful sign in, you will be returned to Oxford Academic.

If you do not have a society account or have forgotten your username or password, please contact your society.

Sign in using a personal account

Some societies use Oxford Academic personal accounts to provide access to their members. See below.

Personal account

A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.

Some societies use Oxford Academic personal accounts to provide access to their members.

Viewing your signed in accounts

Click the account icon in the top right to:

• View your signed in personal account and access account management features.
• View the institutional accounts that are providing access.

Signed in but can't access content

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.

Institutional account management

For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Purchase

Short-term Access

To purchase short-term access, please sign in to your personal account above.

Don't already have a personal account? Register

Body Size and Risk of Colon and Rectal Cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC) - 24 Hours access

EUR €38.00

GBP £33.00

USD $41.00

Rental

This article is also available for rental through DeepDyve.

Citations

Views

Altmetric

Metrics

Total Views 4,360

3,135 Pageviews

1,225 PDF Downloads

Since 12/1/2016

Citations

409 Web of Science

×

Email alerts

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic