The nucleotide sequences of several tRNA genes from rat mitochondria: common features and relatedness to homologous species (original) (raw)
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Centro di Studio sui Mitocondri e Metabolismo Energetico, Istituto di Chimica Biologica, Università di Bari
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Centro di Studio sui Mitocondri e Metabolismo Energetico, Istituto di Chimica Biologica, Università di Bari
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Centro di Studio sui Mitocondri e Metabolismo Energetico, Istituto di Chimica Biologica, Università di Bari
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2
Dipartimento di Biologia Cellulare, Università della Calabria
Cosenza, Italy
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Laboratory of Physiological Chemistry, State University
Groningen, The Netherlands
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Laboratory of Physiological Chemistry, State University
Groningen, The Netherlands
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Centro di Studio sui Mitocondri e Metabolismo Energetico, Istituto di Chimica Biologica, Università di Bari
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1
Centro di Studio sui Mitocondri e Metabolismo Energetico, Istituto di Chimica Biologica, Università di Bari
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,
2
Dipartimento di Biologia Cellulare, Università della Calabria
Cosenza, Italy
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,
1
Centro di Studio sui Mitocondri e Metabolismo Energetico, Istituto di Chimica Biologica, Università di Bari
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Received:
23 February 1982
Revision received:
30 April 1982
PDF Cite
P. Cantatore, C. De Benedetto, G. Gadaleta, R. Gallerani, A.M. Kroon, M. Holtrop, C. Lanave, G. Pepe, C. Quagliariello, C. Saccone, E. Sbisa, The nucleotide sequences of several tRNA genes from rat mitochondria: common features and relatedness to homologous species, Nucleic Acids Research, Volume 10, Issue 10, 25 May 1982, Pages 3279–3289, https://doi.org/10.1093/nar/10.10.3279
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Abstract
We have determined the nucleotide sequences of thirteen rat mt tRNA genes. The features of the primary and secondary structures of these tRNAs show that those for Gln, Ser, and f-Met resemble, while those for Lys, Cys, and Trp depart strikingly from the universal type. The remainder are slightly abnormal. Among many mammalian mt DNA sequences, those of mt tRNA genes are highly conserved, thus suggesting for those genes an additional, perhaps regulatory, function. A simple evolutionary relationship between the tRNAs of animal mitochondria and those of eukaryotic cytoplasm, of lower eukaryotic mitochondria or of prokaryotes, is not evident owing to the extreme divergence of the tRNA sequences in the two groups. However, a slightly higher homology does exist between a few animal mt tRNAs and those from prokaryotes or from lower eukaryotic mitochondria.
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