Sequence of the N2 neuraminidase from influenza virus A/NT/60/68 (original) (raw)

Journal Article

D.R. Bentley ,

Sir William Dunn School of Pathology, University of Oxford

South Parks Road, Oxford OX1 3RE

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G.G. Brownlee

Sir William Dunn School of Pathology, University of Oxford

South Parks Road, Oxford OX1 3RE

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Revision received:

22 July 1982

Published:

25 August 1982

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Abstract

The complete sequence of the neuraminidase gene of influenza virus A/NT/60/68 (N2 subtype) was determined following.cloning of full length commplementary DNA into pBR322. Comparison of the predicted amino acid squence with a closely related neuraminidase from A/Udron/72 suggests that point mutations over an extensive region of the primary sequence can contribute to antigenic drift, although the region between amino acid residues 308 and 371 may be particularly significant.

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