The human ubiquitin gene family: structure of a gene and pseudogenes from the Ub B subfamily (original) (raw)
Journal Article
,
Department of Human Genetics, John Curtin School of Medical Research, Australian National University
PO Box 334, Canberra 2601, Australia
Search for other works by this author on:
Department of Human Genetics, John Curtin School of Medical Research, Australian National University
PO Box 334, Canberra 2601, Australia
Search for other works by this author on:
Received:
14 November 1986
Accepted:
12 December 1986
Published:
26 January 1987
Cite
Rohan T. Baker, Philip G. Board, The human ubiquitin gene family: structure of a gene and pseudogenes from the Ub B subfamily, Nucleic Acids Research, Volume 15, Issue 2, 26 January 1987, Pages 443–463, https://doi.org/10.1093/nar/15.2.443
Close
Navbar Search Filter Mobile Enter search term Search
Abstract
An ubiquitin cDNA clone was isolated from a human liver cDNA library. This clone contained two complete, and a portion of a third, ubiquitin coding sequences joined head to tail with no spacer peptides. Screening a human genomic library with a probe derived from the coding region of this cDNA identified a large number of cross-hybridising clones. Differential screening of these genomic clones with the 3′ non-coding region of the cDNA identified three different 3′-positive clones. Sequence analysis of these three clones revealed: (i) a gene corresponding to the cDNA containing an intron in the 5′ non-coding region and coding for three direct repeats of mature ubiquitin, and (ii) two related pseudogenes which appear to have arisen by reverse transcription and insertion into the genome. However, one pseudogene contains two repeats of the ubiquitin coding sequence, while the other contains only one. Hybridisation analysis of restricted human genomic DNA suggests the presence of one other closely related gene within the genome.
This content is only available as a PDF.
© IRL Press Limited
I agree to the terms and conditions. You must accept the terms and conditions.
Submit a comment
Name
Affiliations
Comment title
Comment
You have entered an invalid code
Thank you for submitting a comment on this article. Your comment will be reviewed and published at the journal's discretion. Please check for further notifications by email.
Citations
Views
Altmetric
Metrics
Total Views 326
212 Pageviews
114 PDF Downloads
Since 1/1/2017
Month: | Total Views: |
---|---|
January 2017 | 1 |
February 2017 | 7 |
March 2017 | 6 |
April 2017 | 2 |
May 2017 | 4 |
June 2017 | 1 |
August 2017 | 2 |
September 2017 | 8 |
October 2017 | 2 |
November 2017 | 1 |
December 2017 | 41 |
January 2018 | 44 |
February 2018 | 45 |
March 2018 | 43 |
April 2018 | 36 |
June 2018 | 1 |
July 2018 | 1 |
August 2018 | 2 |
October 2018 | 1 |
May 2019 | 1 |
June 2019 | 1 |
August 2019 | 1 |
September 2019 | 2 |
October 2019 | 1 |
March 2020 | 2 |
June 2020 | 1 |
January 2021 | 1 |
March 2021 | 2 |
June 2021 | 1 |
November 2021 | 1 |
December 2021 | 1 |
January 2022 | 1 |
March 2022 | 2 |
June 2022 | 2 |
September 2022 | 2 |
October 2022 | 2 |
November 2022 | 2 |
December 2022 | 1 |
January 2023 | 2 |
February 2023 | 2 |
May 2023 | 2 |
June 2023 | 5 |
August 2023 | 2 |
November 2023 | 1 |
January 2024 | 1 |
March 2024 | 2 |
April 2024 | 4 |
May 2024 | 4 |
June 2024 | 6 |
July 2024 | 6 |
August 2024 | 4 |
September 2024 | 5 |
October 2024 | 5 |
Citations
143 Web of Science
×
Email alerts
Citing articles via
More from Oxford Academic