The immunosuppressives FK 506 and cyclosporin A inhibit the generation of protein factors binding to the two purine boxes of the interleukin 2 enhancer (original) (raw)

Journal Article

,

Institut f€r Virologie und Immunbiologie der Universität W€rzburg

Versbacher Strasse 7, D-87 W€rzburg, FRG

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,

Institut f€r Virologie und Immunbiologie der Universität W€rzburg

Versbacher Strasse 7, D-87 W€rzburg, FRG

Search for other works by this author on:

Institut f€r Virologie und Immunbiologie der Universität W€rzburg

Versbacher Strasse 7, D-87 W€rzburg, FRG

* To whom correspondence should be addressed

Search for other works by this author on:

Received:

01 October 1990

Revision received:

04 December 1990

Accepted:

04 December 1990

Published:

11 January 1991

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Thomas Brabletz, Ilona Pietrowski, Edgar Serfling, The immunosuppressives FK 506 and cyclosporin A inhibit the generation of protein factors binding to the two purine boxes of the interleukin 2 enhancer, Nucleic Acids Research, Volume 19, Issue 1, 11 January 1991, Pages 61–67, https://doi.org/10.1093/nar/19.1.61
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Abstract

Like Cyclosporin A (CsA), the macrollde FK 506 is a potent immunosuppresslve that inhibits early steps of T cell activation, including the synthesis of Interleukin 2 (II-2) and numerous other lymphokines. The block of 11-2 synthesis occurs at the transcriptlonal level. At concentrations that block T cell activation, FK 506 and CsA inhibit the proto-enhancer activity of Purine boxes of the 11-2 promoter and the generation of lymphocyte-specific factors binding to the Purine boxes. Under the same conditions, the DNA binding of other 11-2 enhancer factors remains unaffected by both compounds. These results support the view that FK 506 and CsA, which both inhibit the activity of peptidylprolyl cls/trans isomerases, suppress T cell activation by a similar, if not identical mechanism.

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© 1991 Oxford University Press

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