Strong conservation of non-coding sequences during vertebrates evolution: potential involvement in post-transcriptional regulation of gene expression (original) (raw)
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Laboratoire de Biométrie,Génétique et Biologie des Populations,Université Claude Bernard
Lyon I, URA-CNRS 243 Bat 741, 43 Bd du 11 Novembre 1918, 69622 Villeurbanne cedex, France
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,
Laboratoire de Biométrie,Génétique et Biologie des Populations,Université Claude Bernard
Lyon I, URA-CNRS 243 Bat 741, 43 Bd du 11 Novembre 1918, 69622 Villeurbanne cedex, France
Search for other works by this author on:
Laboratoire de Biométrie,Génétique et Biologie des Populations,Université Claude Bernard
Lyon I, URA-CNRS 243 Bat 741, 43 Bd du 11 Novembre 1918, 69622 Villeurbanne cedex, France
Search for other works by this author on:
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Laurent Duret, Franck Dorkeld, Christian Gautier, Strong conservation of non-coding sequences during vertebrates evolution: potential involvement in post-transcriptional regulation of gene expression, Nucleic Acids Research, Volume 21, Issue 10, 25 May 1993, Pages 2315–2322, https://doi.org/10.1093/nar/21.10.2315
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Abstract
Comparison of nucleotide sequences from different classes of vertebrates that diverged more than 300 million years ago, revealed the existence of highly conserved regions (HCRs) with more than 70% similarity over 100 to 1450 nt In non-coding parts of genes. Such a conservation Is unexpected because It Is much longer and stronger than what Is necessary for specifying the binding of a regulatory protein. HCRs are relatively frequent, particularly In genes that are essential to cell life. In multigene families, conserved regions are specific of each isotype and are probably involved In the control of their specific pattern of expression. Studying HCRs distribution within genes showed that functional constraints are generally much stronger In 3′-non−codlng regions than In promoters or Introns. The 3′-HCRs are particularly A + T−rich and are always located In the transcribed untranslated regions of genes, which suggests that they are involved In post−transcrlptional processes. However, current knowledge of mechanisms that regulate mRNA export, localisation, translation, or degradation is not sufficient to explain the strong functional constraints that we have characterised.
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