Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor (original) (raw)
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Department of Biochemistry, Saitama Medical School
38 Moro-Hongo, Moroyama-machi, Iruma-gun, Saitama 350-04, Japan
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Received:
23 February 1994
Revision received:
26 April 1994
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Harumi Chiba, Masami Muramatsu, Akio Nomoto, Hiroyuki Kato, Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor, Nucleic Acids Research, Volume 22, Issue 10, 25 May 1994, Pages 1815–1820, https://doi.org/10.1093/nar/22.10.1815
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Abstract
A set of genes (SWI1, SWI2/SNF2, SWI3, SNF5 and SNF6) in Saccharomyces cerevisiae are required for transcription of a variety of yeast genes. It was recently reported that the mammalian glucocorticoid receptor failed to activate transcription when transiently expressed in swi1−, swi2− or swi3− yeast strains. We report here that two highly related human cDNAs, hSNF2α and -β, encode amino acid sequences homologous to both the yeast SWI2/SNF2 and the Drosophila brahma. Similar to their yeast and Drosophila counterparts, both human cDNAs contain helicase motifs, a bromodomain, a highly charged C-terminal sequence and an N-terminal sequence rich in proline, glutamine and glycine. Tissue distribution of the mRNAs varied slightly. Transcriptional activation by the estrogen receptor and the retinoic acid receptor was enhanced by co-expression of either hSNF2 cDNA. No enhancement was observed for promoters which do not respond to nuclear receptors. We suggest that global transcriptional coactivators equivalent to the yeast SWI/SNF complex exist in mammalian cells.
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