DNA associated with hyperacetylated histone is preferentially digested by DNase I (original) (raw)

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Department of Biochemistry, School of Medicine, University of Iowa

Iowa City, IA 52242, USA

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Department of Biochemistry, School of Medicine, University of Iowa

Iowa City, IA 52242, USA

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Linda Sealy, Roger Chalkley, DNA associated with hyperacetylated histone is preferentially digested by DNase I, Nucleic Acids Research, Volume 5, Issue 6, 1 June 1978, Pages 1863–1876, https://doi.org/10.1093/nar/5.6.1863
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Abstract

Butyrate-treated cells qive rise to massive hyperacetylation of histones and have been used to test the idea that regions of DNA in association with hyperacetylated histones are preferentially solubilized upon digestion with DNase I. Such hyperacetylated histones can be derived from both pre-existing histones or from histone newly synthesized in the presence of butyrate which leads to extreme modification. The DNA in association with both types of hypermodified histone is equally and selectively digested.

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