Human immunoglobulin heavy chain genes: evolutionary comparisons of Cμ, Cδ and Cγ genes and associated switch sequences (original) (raw)
Journal Article
,
Laboratory of Molecular Biology
The MRC Centre, Hills Road, Cambridge CB2 2QH, UK
Search for other works by this author on:
,
Laboratory of Molecular Biology
The MRC Centre, Hills Road, Cambridge CB2 2QH, UK
Search for other works by this author on:
Laboratory of Molecular Biology
The MRC Centre, Hills Road, Cambridge CB2 2QH, UK
Search for other works by this author on:
*Permanent address: Institute of Animal Physiology, Babraham, Cambridge, UK
Published:
25 September 1981
PDF Cite
T.H. Rabbitts, A. Forster, Celia P. Milstein, Human immunoglobulin heavy chain genes: evolutionary comparisons of Cμ, Cδ and Cγ genes and associated switch sequences, Nucleic Acids Research, Volume 9, Issue 18, 25 September 1981, Pages 4509–4524, https://doi.org/10.1093/nar/9.18.4509
Close
Navbar Search Filter Mobile Enter search term Search
Abstract
Human immunoglobulin heavy chain constant region genes have been characterised in isolated clones. The human Cμ gene comprises discrete domains for Cμ1, Cμ2, Cμ3 and Cμ4 + tp separated by short intervening sequences. The Cδ gene has been located about 5 kb downstream of Cμ4. Furthermore, the coding segments for the membrane form of μ have been located 1.9 kb downstream of Cμ4. Tandemly repeated sequences implicated in the heavy chain class switch occur upstream of the Cμ and the Cγ genes, but none were detected near the Cδ gene. These tandem repeats are very homologous to those of mouse. Particularly common is the sequence G-A-G-C-T. These data suggest that the μ to γ switch in humans involves DNA rearrangements of the CH-genes and subsequent deletion of DNA, but that the coexpression of Cμ and Cδ genes results from different mechanisms.
This content is only available as a PDF.
Author notes
*Permanent address: Institute of Animal Physiology, Babraham, Cambridge, UK
© IRL Press Limited
I agree to the terms and conditions. You must accept the terms and conditions.
Submit a comment
Name
Affiliations
Comment title
Comment
You have entered an invalid code
Thank you for submitting a comment on this article. Your comment will be reviewed and published at the journal's discretion. Please check for further notifications by email.
Citations
Views
Altmetric
Metrics
Total Views 113
36 Pageviews
77 PDF Downloads
Since 1/1/2017
| Month: | Total Views: |
|---|---|
| January 2017 | 2 |
| February 2017 | 1 |
| March 2017 | 4 |
| April 2017 | 3 |
| July 2017 | 3 |
| August 2017 | 1 |
| September 2017 | 3 |
| October 2017 | 3 |
| November 2017 | 2 |
| December 2017 | 5 |
| January 2018 | 10 |
| February 2018 | 7 |
| March 2018 | 11 |
| April 2018 | 7 |
| June 2018 | 1 |
| July 2018 | 1 |
| December 2018 | 1 |
| October 2020 | 3 |
| April 2021 | 1 |
| July 2021 | 1 |
| April 2022 | 3 |
| August 2022 | 1 |
| September 2022 | 1 |
| October 2022 | 3 |
| November 2022 | 3 |
| December 2022 | 3 |
| April 2023 | 1 |
| September 2023 | 1 |
| April 2024 | 3 |
| May 2024 | 4 |
| June 2024 | 5 |
| July 2024 | 6 |
| August 2024 | 4 |
| September 2024 | 5 |
Citations
217 Web of Science
×
Email alerts
Citing articles via
More from Oxford Academic