TGF-β downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patients (original) (raw)

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Department of Neurological Surgery, University of California–San Francisco, San Francisco, California (C.A.C., S.J.H., J.J.B., B.J.A., A.T.P.); Department of Microbiology and Immunology and the Cancer Research Institute, University of California–San Francisco, San Francisco, California (L.L.L.)

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Department of Neurological Surgery, University of California–San Francisco, San Francisco, California (C.A.C., S.J.H., J.J.B., B.J.A., A.T.P.); Department of Microbiology and Immunology and the Cancer Research Institute, University of California–San Francisco, San Francisco, California (L.L.L.)

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Department of Neurological Surgery, University of California–San Francisco, San Francisco, California (C.A.C., S.J.H., J.J.B., B.J.A., A.T.P.); Department of Microbiology and Immunology and the Cancer Research Institute, University of California–San Francisco, San Francisco, California (L.L.L.)

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Department of Neurological Surgery, University of California–San Francisco, San Francisco, California (C.A.C., S.J.H., J.J.B., B.J.A., A.T.P.); Department of Microbiology and Immunology and the Cancer Research Institute, University of California–San Francisco, San Francisco, California (L.L.L.)

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Department of Neurological Surgery, University of California–San Francisco, San Francisco, California (C.A.C., S.J.H., J.J.B., B.J.A., A.T.P.); Department of Microbiology and Immunology and the Cancer Research Institute, University of California–San Francisco, San Francisco, California (L.L.L.)

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Department of Neurological Surgery, University of California–San Francisco, San Francisco, California (C.A.C., S.J.H., J.J.B., B.J.A., A.T.P.); Department of Microbiology and Immunology and the Cancer Research Institute, University of California–San Francisco, San Francisco, California (L.L.L.)

Corresponding Author: Andrew Parsa, MD, PhD,

Department of Neurological Surgery

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University of California–San Francisco

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513 Parnassus Avenue, HSW 518, San Francisco, California 94143

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Published:

05 November 2009

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Courtney A. Crane, Seunggu J. Han, Jeffery J. Barry, Brian J. Ahn, Lewis L. Lanier, Andrew T. Parsa, TGF-β downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patients, Neuro-Oncology, Volume 12, Issue 1, January 2010, Pages 7–13, https://doi.org/10.1093/neuonc/nop009
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Abstract

The activating receptor NKG2D, expressed by natural killer (NK) cells and CD8+ T cells, has a role in the specific killing of transformed cells. We examined NKG2D expression in patients with glioblastoma multiforme and found that NKG2D was downregulated on NK cells and CD8+ T cells. Expression of NKG2D on lymphocytes significantly increased following tumor resection and correlated with an increased ability to kill NKG2D ligand-positive tumor targets. Despite the presence of soluble NKG2D ligands in the sera of glioblastoma patients, NKG2D downregulation was primarily caused by tumor-derived tumor growth factor-β, suggesting that blocking of this cytokine may have therapeutic benefit.

© The Author(s) 2009. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

Topic:

• cytokine
• glioblastoma
• down-regulation
• glioma
• natural killer cells
• ligands
• lymphocytes
• t-lymphocytes
• neoplasms
• tumor growth
• serum
• tumor excision
• killing

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