Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease (original) (raw)

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F. Pistollato , S.S. Cano , I. Elio , M.M. Vergara , F. Giampieri , and M. Battino are with the Centre for Nutrition and Health, Universidad Europea del Atlántico, Santander, Spain. S.S. Cano and I. Elio are with the Universidad Internacional Iberoamericana (UNINI), Campeche, Mexico and the Fundacion Universitaria Iberoamericana (FUNIBER), Barcelona, Spain. M.M. Vergara is with the Universidad Internacional Iberoamericana (UNINI), Arecibo, Puerto Rico, USA. F. Giampieri and M. Battino are with the Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche, Sez. Biochimica, Università Politecnica delle Marche, Ancona, Italy.

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F. Pistollato , S.S. Cano , I. Elio , M.M. Vergara , F. Giampieri , and M. Battino are with the Centre for Nutrition and Health, Universidad Europea del Atlántico, Santander, Spain. S.S. Cano and I. Elio are with the Universidad Internacional Iberoamericana (UNINI), Campeche, Mexico and the Fundacion Universitaria Iberoamericana (FUNIBER), Barcelona, Spain. M.M. Vergara is with the Universidad Internacional Iberoamericana (UNINI), Arecibo, Puerto Rico, USA. F. Giampieri and M. Battino are with the Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche, Sez. Biochimica, Università Politecnica delle Marche, Ancona, Italy.

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F. Pistollato , S.S. Cano , I. Elio , M.M. Vergara , F. Giampieri , and M. Battino are with the Centre for Nutrition and Health, Universidad Europea del Atlántico, Santander, Spain. S.S. Cano and I. Elio are with the Universidad Internacional Iberoamericana (UNINI), Campeche, Mexico and the Fundacion Universitaria Iberoamericana (FUNIBER), Barcelona, Spain. M.M. Vergara is with the Universidad Internacional Iberoamericana (UNINI), Arecibo, Puerto Rico, USA. F. Giampieri and M. Battino are with the Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche, Sez. Biochimica, Università Politecnica delle Marche, Ancona, Italy.

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F. Pistollato , S.S. Cano , I. Elio , M.M. Vergara , F. Giampieri , and M. Battino are with the Centre for Nutrition and Health, Universidad Europea del Atlántico, Santander, Spain. S.S. Cano and I. Elio are with the Universidad Internacional Iberoamericana (UNINI), Campeche, Mexico and the Fundacion Universitaria Iberoamericana (FUNIBER), Barcelona, Spain. M.M. Vergara is with the Universidad Internacional Iberoamericana (UNINI), Arecibo, Puerto Rico, USA. F. Giampieri and M. Battino are with the Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche, Sez. Biochimica, Università Politecnica delle Marche, Ancona, Italy.

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F. Pistollato , S.S. Cano , I. Elio , M.M. Vergara , F. Giampieri , and M. Battino are with the Centre for Nutrition and Health, Universidad Europea del Atlántico, Santander, Spain. S.S. Cano and I. Elio are with the Universidad Internacional Iberoamericana (UNINI), Campeche, Mexico and the Fundacion Universitaria Iberoamericana (FUNIBER), Barcelona, Spain. M.M. Vergara is with the Universidad Internacional Iberoamericana (UNINI), Arecibo, Puerto Rico, USA. F. Giampieri and M. Battino are with the Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche, Sez. Biochimica, Università Politecnica delle Marche, Ancona, Italy.

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F. Pistollato , S.S. Cano , I. Elio , M.M. Vergara , F. Giampieri , and M. Battino are with the Centre for Nutrition and Health, Universidad Europea del Atlántico, Santander, Spain. S.S. Cano and I. Elio are with the Universidad Internacional Iberoamericana (UNINI), Campeche, Mexico and the Fundacion Universitaria Iberoamericana (FUNIBER), Barcelona, Spain. M.M. Vergara is with the Universidad Internacional Iberoamericana (UNINI), Arecibo, Puerto Rico, USA. F. Giampieri and M. Battino are with the Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche, Sez. Biochimica, Università Politecnica delle Marche, Ancona, Italy.

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Published:

15 September 2016

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Francesca Pistollato, Sandra Sumalla Cano, Iñaki Elio, Manuel Masias Vergara, Francesca Giampieri, Maurizio Battino, Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease, Nutrition Reviews, Volume 74, Issue 10, October 2016, Pages 624–634, https://doi.org/10.1093/nutrit/nuw023
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Abstract

It has been hypothesized that alterations in the composition of the gut microbiota might be associated with the onset of certain human pathologies, such as Alzheimer disease, a neurodegenerative syndrome associated with cerebral accumulation of amyloid-β fibrils. It has been shown that bacteria populating the gut microbiota can release significant amounts of amyloids and lipopolysaccharides, which might play a role in the modulation of signaling pathways and the production of proinflammatory cytokines related to the pathogenesis of Alzheimer disease. Additionally, nutrients have been shown to affect the composition of the gut microbiota as well as the formation and aggregation of cerebral amyloid-β. This suggests that modulating the gut microbiome and amyloidogenesis through specific nutritional interventions might prove to be an effective strategy to prevent or reduce the risk of Alzheimer disease. This review examines the possible role of the gut in the dissemination of amyloids, the role of the gut microbiota in the regulation of the gut–brain axis, the potential amyloidogenic properties of gut bacteria, and the possible impact of nutrients on modulation of microbiota composition and amyloid formation in relation to the pathogenesis of Alzheimer disease.

© The Author(s) 2016. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Topic:

• amyloid
• alzheimer's disease
• bacteria
• brain
• nutrients
• microbiome
• symptom onset

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