Smoking, atherosclerosis and risk of abdominal aortic aneurysm (original) (raw)

Journal Article

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*

Wolfson Unit for Prevention of Peripheral Vascular Diseases, Department of Public Health Sciences, Medical School

Edinburgh, U.K.

Correspondence: Dr Amanda Lee, Wolfson Unit for Prevention of Peripheral Vascular Diseases, Department of Public Health Sciences, Medical School, Teviot Place, Edinburgh EH8 9AG, U.K.

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,

*

Wolfson Unit for Prevention of Peripheral Vascular Diseases, Department of Public Health Sciences, Medical School

Edinburgh, U.K.

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,

*

Wolfson Unit for Prevention of Peripheral Vascular Diseases, Department of Public Health Sciences, Medical School

Edinburgh, U.K.

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,

*

Wolfson Unit for Prevention of Peripheral Vascular Diseases, Department of Public Health Sciences, Medical School

Edinburgh, U.K.

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†

Department of Radiology, The Royal Infirmary of Edinburgh NHS Trust

Lauriston Place, Edinburgh, U.K.

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Revision received:

04 June 1996

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A. J. Lee, F. G. R. Fowkes, M. N. Carson, G. C. Leng, P. L. Allan, Smoking, atherosclerosis and risk of abdominal aortic aneurysm, European Heart Journal, Volume 18, Issue 4, April 1997, Pages 671–676, https://doi.org/10.1093/oxfordjournals.eurheartj.a015314
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Abstract

Aims

The role of cardiovascular risk factors and atherosclerosis in the aetiology of abdominal aortic aneurysms is not well understood. The aim of this study was to determine the association between atherosclerosis and aortic aneurysm in the general population and the extent to which cardiovascular risk factors might increase the risk of aneurysm independently of an effect on atherosclerotic disease.

Methods and Results

In the Edinburgh Artery Study, 1592 men and women aged 55–74 years were followed prospectively over a period of 5 years. Forty subjects were identified as having an abdominal aortic aneurysm and, for each, five controls were randomly selected. Cases showed a higher prevalence of cardiovascular disease (_P_≤0·001) and had a lower ankle brachial pressure index (_P_≤0·01). Current and recent ex-cigarette smokers had an increased risk of aortic aneurysm compared with long time ex-smokers and never smokers (odds ratio 3·08, 95% CI 1·53 to 6·21 Adjustment for concurrent atherosclerotic disease reduced the odds ratio to 2·63 (95% CI 1·26 to 5·45). The risk of aortic aneurysm was not related to elevation in diastolic blood pressure or in serum cholesterol.

Conclusions

These findings indicate that atherosclerotic disease is associated with risk of aortic aneurysm in the general population. In addition, cigarette smoking appears to have a direct effect on the risk of aortic aneurysm which is independent of atherosclerosis.

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© 1997 The European Society of Cardiology

Topic:

• abdominal aortic aneurysm
• aortic aneurysm
• atherosclerosis
• smoking
• cardiovascular diseases
• heart disease risk factors
• aneurysm
• ankle
• diastolic blood pressure
• serum cholesterol measurement
• cigarettes
• causality

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