Statistical analysis of mammalian pre-mRNA splicing sites (original) (raw)

Journal Article

M.S. Gelfand

Institute of Protein Research, USSR Academy of Sciences

Puschino, Moscow region 142292, USSR

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Received:

04 February 1989

Revision received:

22 June 1989

Published:

11 August 1989

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Abstract

222 donor and 222 acceptor (including 206 pairs) non-homologous splicing sites were studied. Well known features of these were confirmed and some novel observations were made. It is (1) cCAGGGag signal in (−60)–(−58) region of acceptor sites; (2) strong complementarity between regions (−69)–(−55) and (−36)–(−22) of some of the acceptor sites, and (3) small but statistically significant correlation between discrimination energies of corresponding donor and acceptor sites.

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