SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of “cancer cells with neural stemness” in a p53-dependent manner (original) (raw)

Ji-Seon Lee ,

Department of Life Sciences

,

Sogang University

,

Seoul

,

Korea

(J.-S.L., J.-R.P., O.-S.K., H.-J.C.);

Laboratory of Cancer and Stem Cell Biology

,

Sejong University

,

Seoul

,

Korea

(T.-H.L.);

Department of Neurological Surgery

,

The Ohio State University

,

Columbus, Ohio

, (I.N.);

Subteam for Manipulation of Cell Fate, RIKEN BioResource Center

,

Wako

,

Japan

(H.M.);

Gachon Institute of Pharmaceutical Sciences

,

Gachon University

,

Incheon

,

Korea

(K.-H.C.);

Divisions of Radiation Cancer Research

,

Korea Institute of Radiological and Medical Sciences

,

Seoul

,

Korea

(M.-J.P.);

College of Medicine

,

Chung-Ang University

,

Seoul

,

Korea

(H.J.L., S.U.K.);

Division of Neurology, Department of Medicine

,

University of British Columbia

,

Vancouver, British Columbia

,

Canada

(H.J.L., S.U.K.)

Corresponding Author: Hyuk-Jin Cha, PhD, Department of Life Sciences, Sogang University, Seoul 121-742, Korea ([email protected]).

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Jeong-Rak Park ,

Department of Life Sciences

,

Sogang University

,

Seoul

,

Korea

(J.-S.L., J.-R.P., O.-S.K., H.-J.C.);

Laboratory of Cancer and Stem Cell Biology

,

Sejong University

,

Seoul

,

Korea

(T.-H.L.);

Department of Neurological Surgery

,

The Ohio State University

,

Columbus, Ohio

, (I.N.);

Subteam for Manipulation of Cell Fate, RIKEN BioResource Center

,

Wako

,

Japan

(H.M.);

Gachon Institute of Pharmaceutical Sciences

,

Gachon University

,

Incheon

,

Korea

(K.-H.C.);

Divisions of Radiation Cancer Research

,

Korea Institute of Radiological and Medical Sciences

,

Seoul

,

Korea

(M.-J.P.);

College of Medicine

,

Chung-Ang University

,

Seoul

,

Korea

(H.J.L., S.U.K.);

Division of Neurology, Department of Medicine

,

University of British Columbia

,

Vancouver, British Columbia

,

Canada

(H.J.L., S.U.K.)

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Ok-Seon Kwon ,

Department of Life Sciences

,

Sogang University

,

Seoul

,

Korea

(J.-S.L., J.-R.P., O.-S.K., H.-J.C.);

Laboratory of Cancer and Stem Cell Biology

,

Sejong University

,

Seoul

,

Korea

(T.-H.L.);

Department of Neurological Surgery

,

The Ohio State University

,

Columbus, Ohio

, (I.N.);

Subteam for Manipulation of Cell Fate, RIKEN BioResource Center

,

Wako

,

Japan

(H.M.);

Gachon Institute of Pharmaceutical Sciences

,

Gachon University

,

Incheon

,

Korea

(K.-H.C.);

Divisions of Radiation Cancer Research

,

Korea Institute of Radiological and Medical Sciences

,

Seoul

,

Korea

(M.-J.P.);

College of Medicine

,

Chung-Ang University

,

Seoul

,

Korea

(H.J.L., S.U.K.);

Division of Neurology, Department of Medicine

,

University of British Columbia

,

Vancouver, British Columbia

,

Canada

(H.J.L., S.U.K.)

Search for other works by this author on:

Tae-Hee Lee ,

Department of Life Sciences

,

Sogang University

,

Seoul

,

Korea

(J.-S.L., J.-R.P., O.-S.K., H.-J.C.);

Laboratory of Cancer and Stem Cell Biology

,

Sejong University

,

Seoul

,

Korea

(T.-H.L.);

Department of Neurological Surgery

,

The Ohio State University

,

Columbus, Ohio

, (I.N.);

Subteam for Manipulation of Cell Fate, RIKEN BioResource Center

,

Wako

,

Japan

(H.M.);

Gachon Institute of Pharmaceutical Sciences

,

Gachon University

,

Incheon

,

Korea

(K.-H.C.);

Divisions of Radiation Cancer Research

,

Korea Institute of Radiological and Medical Sciences

,

Seoul

,

Korea

(M.-J.P.);

College of Medicine

,

Chung-Ang University

,

Seoul

,

Korea

(H.J.L., S.U.K.);

Division of Neurology, Department of Medicine

,

University of British Columbia

,

Vancouver, British Columbia

,

Canada

(H.J.L., S.U.K.)

Search for other works by this author on:

Ichiro Nakano ,

Department of Life Sciences

,

Sogang University

,

Seoul

,

Korea

(J.-S.L., J.-R.P., O.-S.K., H.-J.C.);

Laboratory of Cancer and Stem Cell Biology

,

Sejong University

,

Seoul

,

Korea

(T.-H.L.);

Department of Neurological Surgery

,

The Ohio State University

,

Columbus, Ohio

, (I.N.);

Subteam for Manipulation of Cell Fate, RIKEN BioResource Center

,

Wako

,

Japan

(H.M.);

Gachon Institute of Pharmaceutical Sciences

,

Gachon University

,

Incheon

,

Korea

(K.-H.C.);

Divisions of Radiation Cancer Research

,

Korea Institute of Radiological and Medical Sciences

,

Seoul

,

Korea

(M.-J.P.);

College of Medicine

,

Chung-Ang University

,

Seoul

,

Korea

(H.J.L., S.U.K.);

Division of Neurology, Department of Medicine

,

University of British Columbia

,

Vancouver, British Columbia

,

Canada

(H.J.L., S.U.K.)

Search for other works by this author on:

Hiroyuki Miyoshi ,

Department of Life Sciences

,

Sogang University

,

Seoul

,

Korea

(J.-S.L., J.-R.P., O.-S.K., H.-J.C.);

Laboratory of Cancer and Stem Cell Biology

,

Sejong University

,

Seoul

,

Korea

(T.-H.L.);

Department of Neurological Surgery

,

The Ohio State University

,

Columbus, Ohio

, (I.N.);

Subteam for Manipulation of Cell Fate, RIKEN BioResource Center

,

Wako

,

Japan

(H.M.);

Gachon Institute of Pharmaceutical Sciences

,

Gachon University

,

Incheon

,

Korea

(K.-H.C.);

Divisions of Radiation Cancer Research

,

Korea Institute of Radiological and Medical Sciences

,

Seoul

,

Korea

(M.-J.P.);

College of Medicine

,

Chung-Ang University

,

Seoul

,

Korea

(H.J.L., S.U.K.);

Division of Neurology, Department of Medicine

,

University of British Columbia

,

Vancouver, British Columbia

,

Canada

(H.J.L., S.U.K.)

Search for other works by this author on:

Kwang-Hoon Chun ,

Department of Life Sciences

,

Sogang University

,

Seoul

,

Korea

(J.-S.L., J.-R.P., O.-S.K., H.-J.C.);

Laboratory of Cancer and Stem Cell Biology

,

Sejong University

,

Seoul

,

Korea

(T.-H.L.);

Department of Neurological Surgery

,

The Ohio State University

,

Columbus, Ohio

, (I.N.);

Subteam for Manipulation of Cell Fate, RIKEN BioResource Center

,

Wako

,

Japan

(H.M.);

Gachon Institute of Pharmaceutical Sciences

,

Gachon University

,

Incheon

,

Korea

(K.-H.C.);

Divisions of Radiation Cancer Research

,

Korea Institute of Radiological and Medical Sciences

,

Seoul

,

Korea

(M.-J.P.);

College of Medicine

,

Chung-Ang University

,

Seoul

,

Korea

(H.J.L., S.U.K.);

Division of Neurology, Department of Medicine

,

University of British Columbia

,

Vancouver, British Columbia

,

Canada

(H.J.L., S.U.K.)

Search for other works by this author on:

Myung-Jin Park ,

Department of Life Sciences

,

Sogang University

,

Seoul

,

Korea

(J.-S.L., J.-R.P., O.-S.K., H.-J.C.);

Laboratory of Cancer and Stem Cell Biology

,

Sejong University

,

Seoul

,

Korea

(T.-H.L.);

Department of Neurological Surgery

,

The Ohio State University

,

Columbus, Ohio

, (I.N.);

Subteam for Manipulation of Cell Fate, RIKEN BioResource Center

,

Wako

,

Japan

(H.M.);

Gachon Institute of Pharmaceutical Sciences

,

Gachon University

,

Incheon

,

Korea

(K.-H.C.);

Divisions of Radiation Cancer Research

,

Korea Institute of Radiological and Medical Sciences

,

Seoul

,

Korea

(M.-J.P.);

College of Medicine

,

Chung-Ang University

,

Seoul

,

Korea

(H.J.L., S.U.K.);

Division of Neurology, Department of Medicine

,

University of British Columbia

,

Vancouver, British Columbia

,

Canada

(H.J.L., S.U.K.)

Search for other works by this author on:

Hong Jun Lee ,

Department of Life Sciences

,

Sogang University

,

Seoul

,

Korea

(J.-S.L., J.-R.P., O.-S.K., H.-J.C.);

Laboratory of Cancer and Stem Cell Biology

,

Sejong University

,

Seoul

,

Korea

(T.-H.L.);

Department of Neurological Surgery

,

The Ohio State University

,

Columbus, Ohio

, (I.N.);

Subteam for Manipulation of Cell Fate, RIKEN BioResource Center

,

Wako

,

Japan

(H.M.);

Gachon Institute of Pharmaceutical Sciences

,

Gachon University

,

Incheon

,

Korea

(K.-H.C.);

Divisions of Radiation Cancer Research

,

Korea Institute of Radiological and Medical Sciences

,

Seoul

,

Korea

(M.-J.P.);

College of Medicine

,

Chung-Ang University

,

Seoul

,

Korea

(H.J.L., S.U.K.);

Division of Neurology, Department of Medicine

,

University of British Columbia

,

Vancouver, British Columbia

,

Canada

(H.J.L., S.U.K.)

Search for other works by this author on:

Seung U. Kim

Department of Life Sciences

,

Sogang University

,

Seoul

,

Korea

(J.-S.L., J.-R.P., O.-S.K., H.-J.C.);

Laboratory of Cancer and Stem Cell Biology

,

Sejong University

,

Seoul

,

Korea

(T.-H.L.);

Department of Neurological Surgery

,

The Ohio State University

,

Columbus, Ohio

, (I.N.);

Subteam for Manipulation of Cell Fate, RIKEN BioResource Center

,

Wako

,

Japan

(H.M.);

Gachon Institute of Pharmaceutical Sciences

,

Gachon University

,

Incheon

,

Korea

(K.-H.C.);

Divisions of Radiation Cancer Research

,

Korea Institute of Radiological and Medical Sciences

,

Seoul

,

Korea

(M.-J.P.);

College of Medicine

,

Chung-Ang University

,

Seoul

,

Korea

(H.J.L., S.U.K.);

Division of Neurology, Department of Medicine

,

University of British Columbia

,

Vancouver, British Columbia

,

Canada

(H.J.L., S.U.K.)

Search for other works by this author on:

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