SEROEPIDEMIOLOGIC SURVEY OF CORONAVIRUS (STRAIN OC 43) RELATED INFECTIONS IN A CHILDREN'S POPULATION (original) (raw)

Journal Article

,

1

From the Respiratory Virology Unit, Laboratory Division, Center for Disease Control, Health Services and Mental Health Administration, Public Health Service; U. S. Department of Health, Education and Welfare, Atlanta

Georgia 30333.

Reprints requests to Mr. Kaye.

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,

1

From the Respiratory Virology Unit, Laboratory Division, Center for Disease Control, Health Services and Mental Health Administration, Public Health Service; U. S. Department of Health, Education and Welfare, Atlanta

Georgia 30333.

Search for other works by this author on:

1

From the Respiratory Virology Unit, Laboratory Division, Center for Disease Control, Health Services and Mental Health Administration, Public Health Service; U. S. Department of Health, Education and Welfare, Atlanta

Georgia 30333.

Search for other works by this author on:

2Present address: Peter Bent Brigham Hospital, Boston, Massachusetts 02115.

Author Notes

Received:

14 December 1970

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Abstract

Kaye, H. S. (CDC, Atlanta, Ga. 30333), H. B. Marsh and W. R. Dowdle. Sero-epidemiologic survey of coronavirus (strain OC 43) related infections in a children's population. Amer J Epid 94: 43–49, 1971.—Acute and convalescent serum pairs and control sera collected from subjects living in a children's home over a 7-year period (1960–1967) were examined by hemagglutination-inhibition (HI) test with coronavirus strain OC 43. Ninety-three serologic conversions were observed; 44 were associated with reported illnesses and 49 with no reported illnesses. In three distinct outbreaks during the winter and spring quarter of 1960–1961, 1964–1965, and 1966–1967, 67 conversions occurred. Seroconversions to strain OC 43 were associated with as much as 19% of the respiratory diseases in a single season. Over the 7-year period coronavirus strain OC 43 accounted for 3% of the total 1328 respiratory illnesses. Evidence of preexisting antibody was apparent in one-third of the children showing seroconversions. The HI test was more sensitive for serodiagnosis than the complement-fixaticn test. The major presenting complaints of the children with respiratory disease associated with coronavirus strain OC 43 were sore throat, cough and coryza; the predominating symptoms were pharyngitis, coryza, fever and cervical adenitis.

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Author notes

2Present address: Peter Bent Brigham Hospital, Boston, Massachusetts 02115.

© 1971, by THE JOHNS HOPKINS UNIVERSITY

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