Membrane-Type Matrix Metalloproteinases (MT-MMPs) in Tumor Metastasis1 (original) (raw)
Journal Article
,
Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University
13-1 Takara-machi, Kanazawa 920
2To whom correspondence should be addressed. Fax: + 81-762-60-7840
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Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University
13-1 Takara-machi, Kanazawa 920
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1This work was supported by the Special Coordination Fund for Promoting Science and Technology from the Ministry of Science and Technology of Japan; by a Grant-in-Aid from the Ministry of Education, Science, and Culture of Japan.
Received:
27 September 1995
Published:
01 February 1996
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Abstract
Activated gelatinase A is reportedly associated with tumor spread. We identified novel matrix metalloproteinases that localize on the cell surface and mediate the activation of progelatinase A. Thus, these progelatinase A activators were named membrane-type matrix metalloproteinase-1 and −2 (MT-MMP-1 and −2, respectively). MT-MMP-1 is overexpressed in malignant tumor tissues, including lung and stomach carcinomas that contain activated gelatinase A. This suggests that MT-MMP-1 is associated with the activation of progelatinase A in these tumor tissues. The expression of MT-MMP-1 also induced binding of gelatinase A to the cell surface by functioning as a receptor. The cell surface localization of proteinases has advantages over pericellular proteolysis. MT-MMP -1 and its family may play a central role in the cell surface localization and activation of progelatinase A and via this mechanism, tumor cell use exogenous progelatinase A to mediate the proteolysis associated with invasion and metastasis.
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Author notes
1This work was supported by the Special Coordination Fund for Promoting Science and Technology from the Ministry of Science and Technology of Japan; by a Grant-in-Aid from the Ministry of Education, Science, and Culture of Japan.
© by the Journal of Biochemistry
Topic:
- lung
- cancer
- carcinoma
- endopeptidases
- gelatinase a
- interstitial collagenase
- matrix metalloproteinases
- tissue membrane
- neoplasm metastasis
- stromelysin 1
- neoplasms
- stomach
- tumor cells
- transcriptional activation
- peptide hydrolases
- proteolysis
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