Neostriatal GABAergic interneurones contain NOS, calretinin ... : NeuroReport (original) (raw)
Motor Systems: PDF Only
Corresponding Author
1Laboratory for Neural Systems, Frontier Research Program, RIKEN, Wako, 351–01;
2Laboratory for Neural Circuits, Bio-mimetic Control Research Center, RIKEN, Atsuta-ku, Nagoya, 456, Japan
Abstract
To reveal functional heterogeneity among GABAergic interneurones in rat neostriatum, we investigated: (1) whether nitric oxide synthase (NOS)- and calretininimmunoreactive cells, like parvalbumin-immunoreactive cells, were also immunoreactive for 67 kD glutamic acid decarboxylase (GAD67 and GABA;(2) whether NOS cells, calretinin cells and parvalbumin cells belonged to separate populations or not. NOS cells, calretinin cells and parvalbumin cells all showed immunoreactivity for GAD67 in colchicine-treated rats. Calretinin cells and parvalbumin cells were also immunoreactive for GABA. Only a few cells (0–3%) showed immunoreactivity for two antigens. These results suggest that the neostriatum has at least three GABAergic interneuronal systems.
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