Biphasic transforming growth factor-β production flanking... : NeuroReport (original) (raw)
Research Papers: Neuroimmunology: PDF Only
Biphasic transforming growth factor-β production flanking the pro-inflammatory cytokine response in cerebral trauma
Rimaniol, Anne-Cécile; Lekieffre, Delphine1; Serrano, André1; Masson, Annie; Benavides, Jesus1; Zavala, FloraCA
INSERM U25, Hôpital Necker, 161 rue de Sèvres, 75743 Paris Cedex 15, France
1Synthelabo Recherche, 31 avenue Paul Vaillant Couturier, 92225 Bagneux Cedex, France
CA Corresponding Author
Abstract
We determined the time-course of the production of transforming growth factor-β (TGF-β) after fluid-percussion injury using a bioassay. Biophasic production of TGF-β composed mainly of TGF-β2 was detected in the ipsilateral cortex, with a first peak 30 min and a second peak 48 h after the lesion, flanking the transient production of tumor necrosis factor-α and interleukin-6 occurring between 5 and 18 h after trauma. This temporal pattern suggested that TGF-β plays alternatively a pro- and anti-inflammatory role in the regulation of the brain cytokine network in response to injury, providing an endogenous mechanism for the control of the inflammatory reaction in traumatic brain injury.
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