A rapid brain metabolic change in infants detected by fMRI : NeuroReport (original) (raw)

Brain Imaging

Yamada, Hiroki1,4; Sadato, Norihiro2; Konishi, Yukuo3; Kimura, Kouki3; Tanaka, Masato1; Yonekura, Yoshiharu2; Ishii, Yasushi1

1Department of Radiology, Fukui Medical School, Fukui, Japan

2Biomedical Imaging Research Center, Fukui Medical School, Fukui, Japan

3Department of Pediatrics, Fukui Medical School, Fukui, Japan

4Corresponding Author: Hiroki Yamada

Received 2 September 1997; accepted 16 September 1997

Abstract

TO determine developmental changes of activity-related metabolism in human visual cortex, we performed functional magnetic resonance imaging (fMRI) from the neonatal period. A rapid metabolic changing pattern accompanying normal human brain maturation was revealed by fMRI with photic stimulation. Infants older than 8 weeks of age showed a stimulus-related signal decrease in the visual cortex, whereas younger neonates showed a signal increase. This inversion of response in infants suggests a change in oxygen consumption during neuronal activation, which is related to rapid synapse formation and accompanying increased metabolism. fMRI can detect dynamic metabolic changes during the brain maturation, and provides a new clue in the detection of abnormal brain development or CNS plasticity.