NR2B-containing NMDA receptors are up-regulated in temporal ... : NeuroReport (original) (raw)
Clinical Neuroscience
Grimwood, Sarah1,3; Slater, Paul2; Deakin, J F. William2; Hutson, Pete H.1
1Merck Sharp & Dohme Neuroscience Research Laboratories, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR
2School of Biological Sciences, Manchester University, Manchester M13 9PT, UK
3Corresponding Author: Sarah Grimwood
Received 28 October 1998; accepted 30 November 1998
Abstract
SATURATION analyses of [3H]L-689,560, [3H]CGP 39653 and NMDA-specific [3H]ifenprodil binding revealed an equivalent increase (0.7 pmol/mg) in the number of [3H]L-689,560 and [3H]ifenprodil binding sites in superior temporal cortex (BA22) from drug-treated chronic schizophrenic patients and control subjects. No differences were observed between control and schizophrenic subjects for [3H]CGP 39653 binding in BA22, or for any of the radioligands binding to pre-motor cortex (BA6). Since [3H]L-689,560, [3H]CGP 39653 and [3H]ifenprodil label the glycine, glutamate and ifenprodil sites of the NMDA receptor complex, which are associated with NR1, NR1/NR2A and NR1/NR2B subunits respectively, our findings suggest that NR2B-containing receptors are selectively up-regulated in superior temporal cortex in schizophrenia.
© 1999 Lippincott Williams & Wilkins, Inc.