Bacteriuria in men infected with HIV-1 is related to their... : AIDS (original) (raw)

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Bacteriuria in men infected with HIV-1 is related to their immune status (CD4+ cell count)

Hoepelman, Andy I.M.*,†; van Buren, Marjolijn*; van den Broek, Jan‡; Borleffs, Jan C.C.*

*Department of Internal Medicine, Section of Immunology and Infection

†Dipar5tment of Clinical Microbiology and Liboratory for infection diseises

‡Centre for Biostatistics, University of Utrecht, The Netherlands.

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Abstract

Objective

Reports from the United States that urinary tract infections (UTI) are more common in homosexual than in heterosexual men have not been confirmed in Europe. The occurrence of several UTI in men infected with HIV-1 has been recorded in The Netherlands. We therefore analysed the relationship between the presence of bacteriuria and the immune status (CD4+ cell count) in these HIV-1-infected patients.

Design

Urinary cultures were obtained prospectively for 2 years, during the first visit and every 6 months thereafter, when signs and symptoms of UTI occurred and when patients had fever of unknown origin. CD4+ cell counts were measured at the same time.

Setting

The study was performed at the University Hospital, Utrecht, The Netherlands.

Patients, participants

One hundred and thirty HIV-1-infected men attended our hospital. Data from 98 were analysed. Eighty-nine (91%) of these men were either homo-or bisexual.

Main outcome measures

Positive urinary culture.

Results

Group 1 (CD4+ cell count <200 × 106/I) consisted of 47 patients; 30% had at least one period of bacteriuria, with 21 episodes. Group 2 (CD4+ cell count 200–500 × 106/l) consisted of 27 patients; 11% had at least one period of bacteriuria, with five episodes. We did not find bacteriuria in the 24 patients in group 3 (CD4+ cell count >500 × 106/l). The rate of bacteriuria per patient-month, 4 (group 1) versus 2 (group 2), differed significantly (P < 0.001). A significant relationship between CD4+ cell count and bacteriuria was found (P = 0.00003); no relationship, however, was found with anal intercourse, hospitalization, Karnofsky score, follow-up, or age.

Conclusion

We conclude that men infected with HIV and presenting with a CD4 + cell count <200 × 106/l are at increased risk for bacteriuria.

© Lippincott-Raven Publishers.