Double-Blind Comparison of the Effects of Clonazepam and... : Journal of Clinical Psychopharmacology (original) (raw)

Double-Blind Comparison of the Effects of Clonazepam and Lorazepam in Acute Mania: PDF Only

Double-Blind Comparison of the Effects of Clonazepam and Lorazepam in Acute Mania

BRADWEJN, JACQUES MD, FRCP(C); SHRIQUI, CHRISTIAN MD, FRCP(C); KOSZYCKI, DIANA MA; METERISSIAN, GREG MD, FRCP(C)

Received November 15, 1989 and accepted April 3, 1990. Address requests for reprints to Dr. Bradwejn, Division of Psychopharmacology, St. Mary's Hospital Center, 3830 LaCombe Ave., Montreal, Quebec, H3T 1M5, Canada.

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Abstract

A double-blind comparison of clonazepam and lorazepam was conducted in 24 patients with acute mania. Patients received either clonazepam or lorazepam alone for 14 days. Treatment with lorazepam produced marked improvement in symptomatology, while treatment with clonazepam failed to demonstrate a significant therapeutic effect. Sixty-one percent of patients responded to treatment with lorazepam, with 38.5% achieving remission. This compares to an 18.2% response rate and 0% remission rate in patients treated with clonazepam. These findings support the usefulness of lorazepam in the treatment of acute mania.

(J Clin Psychopharmacol 1990;10:403-408)

© Williams & Wilkins 1990. All Rights Reserved.