Changes in Brain Energy and Phospholipid Metabolism During Development and Aging in the Fischer 344 Rat (original) (raw)
Journal Article
,
Laboratory of Neurophysics, Department of Psychiatry and Neurology,
University of Pittsburgh
, Pittsburgh, Pennsylvania
Correspondence to: J. W. Pettegrew, M.D., Laboratory ofNeurophysics, Department of Psychiatry and Neurology, University of Pittsburgh, Graduate School of Public Health, 130 DeSoto Street, A741 Crabtree Hall, Pittsburgh, Pennsylvania 15261.
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,
Laboratory of Neurophysics, Department of Psychiatry and Neurology,
University of Pittsburgh
, Pittsburgh, Pennsylvania
Search for other works by this author on:
,
Laboratory of Neurophysics, Department of Psychiatry and Neurology,
University of Pittsburgh
, Pittsburgh, Pennsylvania
Search for other works by this author on:
,
Laboratory of Neurophysics, Department of Psychiatry and Neurology,
University of Pittsburgh
, Pittsburgh, Pennsylvania
Search for other works by this author on:
Laboratory of Neurophysics, Department of Psychiatry and Neurology,
University of Pittsburgh
, Pittsburgh, Pennsylvania
Search for other works by this author on:
Cite
J. W. Pettegrew, K. Panchalingam, G. Withers, D. McKeag, S. Strychor, Changes in Brain Energy and Phospholipid Metabolism During Development and Aging in the Fischer 344 Rat, Journal of Neuropathology & Experimental Neurology, Volume 49, Issue 3, May 1990, Pages 237–249, https://doi.org/10.1097/00005072-199005000-00005
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Abstract
The effects of brain development and aging on high-energy phosphate and membrane phospholipid metabolism were studied from birth to senescence in the Fischer 344 rat using 31P nuclear magnetic resonance spectroscopy. Marked developmental and smaller aging-related changes were observed in brain high-energy phosphates, phospholipid precursors and phospholipid breakdown products. The biochemical changes correlate with known histological and electrophysiological changes occurring in the brain during development (neuritic sprouting and onset of brain electrical activity) and aging (loss of dendritic processes). These findings provide a framework for interpreting the effects of physiological insults during different developmental and aging periods.
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© 1990 by the American Association of Neuropathologists
Topic:
- aging
- nuclear magnetic resonance
- metabolism
- dendrites
- tissue membrane
- phosphates
- phospholipids
- spectrum analysis
- brain
- rats
- electrical activity of brain
- brain development
- symptom onset
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