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Current Issue

November 1, 2024 - Volume 49 - Issue 21

Read the recent research from the Fourth Annual Musculoskeletal Education and Research Center Symposium. The meeting gathered eminent spine surgeons, clinicians, researchers, scientists, and engineers who presented the latest updates in theirfields of expertise creating discussion on a variety of clinically relevant topics such as challenges in musculoskeletal pathology with reference to spinal disorders, innovative research strategies, new implant technologies that are on the horizon, and most importantly, the scientific exchange of ideas and perspectives.Publication support provided by Globus Medical, Inc.

Published April 1, 2018

Other Supplements

December 15, 2017 - Volume 42 -

Explore this special issue which focuses on proceedings from the First Annual Lumbar Total Disc Replacement Summit that was held on October 25, 2016 in Boston, MA. This five-article supplement focuses on the Summit, which brought together seventeen thought-leaders in the spine surgery community. These experts employed a modified-Delphi method to determine where consensus existed pertaining to the utilization of lumbar total disc replacement as a standard of care for a subpopulation of patients suffering from degenerative disc disease. The funding for this supplement was provided by Aesculap Implant Systems, LLC.
Published December 15, 2017

October 15, 2016 - Volume 41 -

The AOSpine Knowledge Forum Tumor (AOSKFT) has built upon the inaugural focus issue in spine oncology by the Spine Oncology Study Group (SOSG) by using the same evidence-based medicine format to introduce new complementary topics, report on practice changing advances and breakthroughs, and reinforce fundamental management principles unique to these complex patients.
Published October 15, 2016

April 1, 2017 - Volume 42 -

Musculoskeletal Education and Research Center Symposium \nGuest Editor: K. Daniel Riew, MD\n\nStart reading this special issue to learn more on the advancements in the surgical treatment of spinal disorders. Prominent spine surgeons and researchers from the 2016 Annual Musculoskeletal Education and Research Center Symposium give you insights on the latest techniques in spinal surgery, and provide you with in-depth basic science topics, such as biomechanics and biologics sharing their expertise and challenges. \n
Published April 1, 2017

October 2016 - Volume 41 -

Minimally Invasive Spine Surgery in China

With nearly two decades of development, Chinese surgeons have accumulated large amount of clinical data and invented quite a few instruments and techniques on MISS. This special issue includes 8 papers in this field authored by Chinese surgeons, with Dr. Wei Tian as Guest Editor.

Published October 2016

April 2016 - Volume 41 - Supplement 8

Minimally Invasive Techniques of Spine Surgery\nGuest Editor: Frank M. Phillips, MD\n\nIn 2010, approximately one of six instrumented spine procedures in the United States was performed with a minimally invasive exposure. In 2016, that number is nearing one in three, with estimates that more than half of all spine procedures will be performed with minimally invasive techniques by 2020. In short, twice as much MIS surgery is being performed today compared to five and a half years ago. With the increasing adoption of MIS techniques, there has been a concomitant increase in the volume and quality of evidence available to guide evidence- and experience-based decision making.\n\nAs with nearly all other surgical specialties, minimally invasive approaches have incrementally replaced open exposures and this similar progression in spine surgery has become undeniable. The cumulative and consistent evidence in this field confirms we are near or at the tipping point of MIS procedures to be increasingly, and at some point solely, used in responsible applications with appropriate techniques in properly selected patients at the most efficient surgical venues.Publication support provided by NuVasive, Inc.\nwww.nuvasive.com
Published April 2016

April 2016 - Volume 41 - Supplement 7

Read the recent research from the Second Annual Musculoskeletal Education and Research Center Symposium, held last August. The Symposium hosted several keynote speakers, including Dr. Hans-Joachim Wilke and Professor Wolfgang Rauschning. Dr. Wilke emphasized the importance of clinicians and basic scientists working together to develop new technologies. Dr. Rauschning utilized his novel cryotome technique and photographic imagery to display relevant surgical anatomy. Several biomechanical engineering scholars, including Dr.Vijay Goel and Dr. Lisa Ferrera, highlighted the role of computational modeling and mechanical testing in establishing standards in the design and evaluation of spinal devices. Dr. Nadim Hallab, an immunologist of musculoskeletal tissue, reported on the host response to implants.
Clinical aspects of the Symposium focused primarily on deformity, especially in the sagittal plane. As a reader you can access the discussions of how to measure deformity and the role of pelvic alignment. Learn about treatment options included osteotomy and lateral approaches, and discussions on the role of biologics and the promise of navigation. Enjoy the debate on the role of rigidity in fixation (rigid vs. semi-rigid).
Read this special issue for FREE now.

Published April 2016

Issue Highlights

In this issue of Spine, Cetik et al present a novel classification system capable of accounting for the different modes of degeneration that potentiate failure at the proximal junction following adult spinal fusion. This new paradigm is a useful rubric for studying and presenting this increasingly common complication following extensive spinal fusion and can help inform best practices regarding correction. In addition, Tobert et al present valuable insights into the management of patients with spinal chondrosarcoma in the modern period. This is a clinical retrospective of the experience at Massachusetts General Hospital between 2007 and 2020. Finally, Zhang et al provide useful information regarding the impact of bacterial infection on the intervertebral disc using a rabbit model. In this study, Cutibacterium acnes infection led to disc degeneration while S. epidermidis inoculation caused discitis. Coinfection with both bacteria also resulted in discitis, but in a more limited capacity than what was experienced with S. epidermidis infection alone.

​​​​​​cropped-SPINEv41s8-cover- April 2016.jpg​Mini​​​​mally Invasive Techniques of Spine Surgery​

Guest Editor: Frank M. Phillips, MD

In 2010, approximately one of six instrumented spine procedures in the United States was performed with a minimally invasive exposure. In 2016, that number is nearing one in three, ​with estimates that more than half of all spine procedures will be performed with minimally invasive techniques by 2020. In short, twice as much MIS surgery is being performed today compared to five and a half years ago. With the increasing adoption of MIS techniques, there has been a concomitant increase in the volume and quality of evidence available to guide evidence- and experience-based decision making.

As with nearly all other surgical specialties, minimally invasive approaches have incrementally replaced open exposures and this similar progression in spine surgery has become undeniable. The cumulative and consistent evidence in this field confirms we are near or at the tipping point of MIS procedures to be increasingly, and at some point solely, used in responsible applications with appropriate techniques in properly selected patients at the most efficient surgical venues.

Publication support provided by NuVasive, Inc.

www.nuvasive.com​​

The Different Influence of Cutibacterium acnes and Staphylococcus epidermidis in the Lumbar Disc: An in Vivo Study in Rabbits

Zhang, Mingtao; Deng, Liangna; Jia, Jingwen; Cao, Zhenyu; Li, Yalong; Zhang, Junfu; He, Xuegang; Lei, Shuanhu; Hu, Xuchang; Kang, Xuewen Less

Spine. 49(21):1488-1496, November 1, 2024.

Chondrosarcoma of the Mobile Spine: An Update on Patients Treated at a Single Institution

Tobert, Daniel G.; Messier, Sidney; Schoenfeld, Andrew J.; More

Tobert, Daniel G.; Messier, Sidney; Schoenfeld, Andrew J.; Bakshi, Chinmay; MacDonald, Shannon M.; Schwab, Joseph H. Less

Spine. 49(21):1475-1482, November 1, 2024.

Proximal Junctional Degeneration and Failure Modes: A Novel Classification and Clinical Implications

Cetik, Riza M.; Glassman, Steven D.; Dimar, John R. II; More

Cetik, Riza M.; Glassman, Steven D.; Dimar, John R. II; Campbell, Mitchell J.; Djurasovic, Mladen; Crawford, Charles H. III; Gum, Jeffrey L.; Owens, R. Kirk II; McCarthy, Kathryn J.; Carreon, Leah Y. Less

Spine. 49(21):1465-1474, November 1, 2024.

Circulating microRNAs May Be Predictive of Degenerative Cervical Myelopathy

Divi, Srikanth N.; Markova, Dessislava Z.; D’Antonio, Nicholas D.; More

Divi, Srikanth N.; Markova, Dessislava Z.; D’Antonio, Nicholas D.; Lambrechts, Mark J.; Levy, Hannah A.; Heard, Jeremy C.; Yalla, Goutham R.; Chang, Michael; Hilibrand, Alan S.; Vaccaro, Alexander R.; Kepler, Christopher K. Less

Spine. 49(20):1393-1400, October 15, 2024.

AI Summary This study aimed to identify unique serum profiles of circulating miRNAs and inflammatory markers in patients with degenerative cervical myelopathy (DCM) compared to healthy controls (HC). Researchers collected venous blood from both groups and analyzed miRNA expression and serum inflammatory profiles. They found 15 differentially expressed miRNAs, focusing on miR-223-3p (upregulated) and miR-451a (downregulated). Gene network analysis linked these miRNAs to neurological disease, with miR-223-3p targeting over 100 genes, including CDKN1B and the insulin receptor. Additionally, DCM patients showed higher levels of pro-inflammatory cytokines. These findings suggest that specific miRNAs and inflammatory markers could be used for future DCM diagnostics or treatments

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Factors Associated With the Maintenance of Cost-effectiveness at Five Years in Adult Spinal Deformity Corrective Surgery

Passias, Peter G.; Mir, Jamshaid M.; Dave, Pooja; More

Passias, Peter G.; Mir, Jamshaid M.; Dave, Pooja; Smith, Justin S.; Lafage, Renaud; Gum, Jeffrey; Line, Breton G.; Diebo, Bassel; Daniels, Alan H.; Hamilton, David Kojo; Buell, Thomas J.; Scheer, Justin K.; Eastlack, Robert K.; Mullin, Jeffrey P.; Mundis, Gregory M.; Hosogane, Naobumi; Yagi, Mitsuru; Schoenfeld, Andrew J.; Uribe, Juan S.; Anand, Neel; Mummaneni, Praveen V.; Chou, Dean; Klineberg, Eric O.; Kebaish, Khaled M.; Lewis, Stephen J.; Gupta, Munish C.; Kim, Han Jo; Hart, Robert A.; Lenke, Lawrence G.; Ames, Christopher P.; Shaffrey, Christopher I.; Schwab, Frank J.; Lafage, Virginie; Hostin, Richard A. Jr; Bess, Shay; Burton, Douglas C.; on behalf of the International Spine Study Group Less

Spine. 49(20):1401-1409, October 15, 2024.

AI Summary This study examined the long-term cost-effectiveness (CE) of surgical treatment for adult spinal deformity (ASD) over a five-year period. Analyzing data from 327 patients, the study found that the average surgery cost was 91,095±91,095±91,095±47,003, with utility gains measured in quality-adjusted life-years (QALY). At two years, the cost per QALY was 414,885,decreasingto414,885, decreasing to 414,885,decreasingto142,058 at five years. By five years, 56% of patients met the CE threshold of $150,000, and 87% met cumulative CE till life expectancy if no revision surgery was needed. Higher baseline comorbidity index (CCI) and pelvic tilt (PT) were significant predictors of not maintaining durable CE. The study concludes that most patients achieve CE after four years, with mechanical complications influencing CE outcomes at two years and comorbidity burden and medical complications at five years

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Postoperative C5 Palsy after Anterior or Posterior Decompression for Degenerative Cervical Myelopathy: A Subgroup Analysis of the Multicenter, Prospective, Randomized, Phase III, CSM-Protect Clinical Trial

Bak, Alex B.; Moghaddamjou, Ali; Alvi, Mohammed; More

Bak, Alex B.; Moghaddamjou, Ali; Alvi, Mohammed; Ahn, Henry; Farhadi, H. Francis; Shaffrey, Christopher I.; Nassr, Ahmad; Mummaneni, Praveen; Arnold, Paul M.; Jacobs, W. Bradley; Riew, K. Daniel; Kelly, Michael; Brodke, Darrel S.; Vaccaro, Alexander R.; Hilibrand, Alan S.; Wilson, Jason; Harrop, James S.; Yoon, S. Tim; Kim, Kee D.; Fourney, Daryl R.; Santaguida, Carlo; Massicotte, Eric M.; Kopjar, Branko; Fehlings, Michael G. Less

Spine. 49(20):1410-1416, October 15, 2024.

AI Summary This retrospective cohort study analyzed data from the CSM-Protect clinical trial to assess the risk of C5 palsy following surgical treatment for degenerative cervical myelopathy (DCM). The study included 283 patients who underwent either anterior or posterior decompression. Results showed that 7.4% of patients developed postoperative C5 palsy, with a significantly higher incidence in the posterior decompression group (11.26%) compared to the anterior group (3.03%). Multivariate analysis indicated that the posterior approach was associated with over four times the risk of C5 palsy. These findings suggest that the choice of surgical approach should consider the higher risk of C5 palsy with posterior decompression

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Efficacy of Biphasic Calcium Phosphate Ceramic With a Needle-Shaped Surface Topography Versus Autograft in Instrumented Posterolateral Spinal Fusion

Stempels, Hilde W.; Lehr, A. Mechteld; Delawi, Diyar; More

Stempels, Hilde W.; Lehr, A. Mechteld; Delawi, Diyar; Hoebink, Eric A.; Wiljouw, Inge A.A.A.; Kempen, Diederik H.R.; van Susante, Job L.C.; Kruyt, Moyo C.; on behalf of the Dutch Clinical Spine Research Group Less

Spine. 49(19):1323-1331, October 1, 2024.

AI Summary This study aimed to determine if MagnetOs Granules, a slowly resorbable biphasic calcium phosphate with submicron microporosity (BCP<μm), are as effective as autografts for instrumented posterolateral fusion (PLF) in the spine. In a multicenter randomized controlled trial involving 100 patients, each patient received BCP<μm on one side and autograft on the other. After one year, the fusion rate per segment was 79% for BCP<μm compared to 47% for autograft. The results showed that BCP<μm was not only noninferior but also superior to autograft, challenging the traditional preference for autologous bone in spinal fusion procedures

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Comparison of Patients Operated for Lumbar Spinal Stenosis With and Without Spondylolisthesis​​​​​: A Secondary Analysis of the NORDSTEN Trials

Weber, Clemens; Hermansen, Erland; Myklebust, Tor Åge; More

Weber, Clemens; Hermansen, Erland; Myklebust, Tor Åge; Banitalebi, Hasan; Brisby, Helena; Brox, Jens I.; Franssen, Eric; Hellum, Christian; Indrekvam, Kari; Harboe, Knut; Rekeland, Frode; Solberg, Tore; Storheim, Kjersti; Austevoll, Ivar M. Less

Spine. 49(19):1332-1338, October 1, 2024.

AI Summary This observational cohort study analyzed data from two randomized trials to compare outcomes in lumbar spinal stenosis patients with and without spondylolisthesis. Conducted at 16 Norwegian hospitals, the study included 704 patients, with 267 having spondylolisthesis and 437 without. Researchers assessed disability, function, pain, quality of life, complication, and reoperation rates up to 2 years post-surgery. Results showed no significant differences in disability, function, back pain, leg pain, or quality of life between the two groups before surgery or at 2-year follow-up. However, complication rates were higher in patients with spondylolisthesis (22.9%) compared to those without (12.1%, P <0.001). Reoperation rates did not differ significantly

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Removals and Revisions of Cervical Total Disc Replacement Devices in a Consecutive Series of 1626 Patients Beginning With the First Case Experience in 2003

Blumenthal, Scott L.; Griffin, Cody; Courtois, Emily C.; More

Blumenthal, Scott L.; Griffin, Cody; Courtois, Emily C.; Guyer, Richard D.; Zigler, Jack E.; Shellock, Jessica L.; Ohnmeiss, Donna D. Less

Spine. 49(19):1348-1351, October 1, 2024.

AI Summary This retrospective cohort study examined the rate of cervical total disc replacement (TDR) device removal or revision in 1626 patients from 2003 to June 2021. The study found that 1.48% of TDRs were removed or revised, with 23 removals (1.41%) and 1 revision (0.06%). Reasons for removal included osteolysis with/without Cutibacterium acnes, device displacement/migration, posterior spinal pathology, metal allergy, approach-related complications, malpositioning, subsidence, and hypermobility. No removals or revisions occurred in patients with a minimum of 10-year follow-up. The removal/revision rate was higher in FDA trials compared to postapproval (4.1% vs. 1.3%, P < 0.05). These findings support the long-term safety of cervical TDR devices

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Impact of Preoperative Symptom Duration on Patient-Reported Outcomes Following Cervical Disc Replacement for Cervical Radiculopathy

Mai, Eric; Kim, Eric T.; Kaidi, Austin; More

Mai, Eric; Kim, Eric T.; Kaidi, Austin; Subramanian, Tejas; Simon, Chad Z.; Asada, Tomoyuki; Kwas, Cole T.; Zhang, Joshua; Araghi, Kasra; Singh, Nishtha; Tuma, Olivia C.; Korsun, Maximilian K.; Allen, Myles R.J.; Heuer, Annika; Sheha, Evan D.; Dowdell, James E.; Huang, Russel C.; Albert, Todd J.; Qureshi, Sheeraz A.; Iyer, Sravisht Less

Spine. 49(18):1251-1258, September 15, 2024.

AI Summary This study reviewed data to assess how the length of preoperative symptoms affects outcomes after cervical disc replacement (CDR) for radiculopathy. It included 201 patients, divided into groups with symptoms lasting less than 6 months and those with symptoms for 6 months or more. Results showed that patients with shorter symptom duration had significantly better improvements in neck disability index (NDI) and visual analog scale (VAS) scores for neck and arm pain in both early (within 3 months) and late (6 months to 2 years) postoperative periods. They also achieved minimal clinically important difference (MCID) more frequently in the early postoperative period. Longer symptom duration was an independent risk factor for not achieving MCID at the latest timepoint. This suggests that earlier surgical intervention may lead to better outcomes

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Benchmark Values for Construct Survival and Complications by Type of ASD Surgery

Bass, Robert Daniel; Lafage, Renaud; Smith, Justin S.; More

Bass, Robert Daniel; Lafage, Renaud; Smith, Justin S.; Ames, Christopher; Bess, Shay; Eastlack, Robert; Gupta, Munish; Hostin, Richard; Kebaish, Khaled; Kim, Han Jo; Klineberg, Eric; Mundis, Gregory; Okonkwo, David; Shaffrey, Christopher; Schwab, Frank; Lafage, Virginie; Burton, Douglas; On behalf of the International Spine Study Group Less

Spine. 49(18):1259-1268, September 15, 2024.

AI Summary This study aimed to establish benchmarks for complication rates based on different types of adult spinal deformity (ASD) surgeries. Using data from a prospective multicenter database, researchers analyzed 1,073 patients out of 1,494 eligible for 2-year follow-up. They categorized surgeries into eight scenarios based on levels treated, previous fusion status, and three-column osteotomy use. Results showed significant differences in construct survival among surgical types, with shorter fusions having better outcomes and UT-pelvis with 3CO having the worst. The study found no significant associations between type of surgery and specific complications like renal, cardiac, infection, wound, gastrointestinal, pulmonary, implant malposition, or neurological issues. These findings can help create benchmarks for ASD surgery, aiding in surgical decisions and patient counseling

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Highest Achievable Outcomes for Adult Spinal Deformity Corrective Surgery: Does Frailty Severity Exert a Ceiling Effect?

Passias, Peter G.; Onafowokan, Oluwatobi O.; Tretiakov, Peter; More

Passias, Peter G.; Onafowokan, Oluwatobi O.; Tretiakov, Peter; Williamson, Tyler; Kummer, Nicholas; Mir, Jamshaid; Das, Ankita; Krol, Oscar; Passfall, Lara; Joujon-Roche, Rachel; Imbo, Bailey; Yee, Timothy; Sciubba, Daniel; Paulino, Carl B.; Schoenfeld, Andrew J.; Smith, Justin S.; Lafage, Renaud; Lafage, Virginie Less

Spine. 49(18):1269-1274, September 15, 2024.

AI Summary This retrospective single-center study examined how frailty affects outcomes after adult spinal deformity (ASD) corrective surgery. Researchers analyzed 393 ASD patients, categorized as Not Frail (NF), Frail (F), and Severely Frail (SF), and tracked their Oswestry Disability Index (ODI) scores over two years. Results showed that SF patients had the highest deterioration rate (16.7%, P=0.025) but initially improved the most at six months (ΔODI of −22.6±18.0, P<0.001). However, NF and F patients achieved maximal ODI improvement at two years. Kaplan-Meier analysis indicated that increasing frailty correlated with shorter times to major complications or reoperations. The study concludes that severe frailty limits overall improvement and maintenance post-surgery, suggesting a ceiling effect

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Correlation of Radiographic Healing on Advanced Imaging in Young Adults and Adolescents With Symptomatic Spondylolysis Before and After Treatment: A Retrospective Study

Gauthier, Chase; Bakaes, Yianni; Puckett, Haley; More

Gauthier, Chase; Bakaes, Yianni; Puckett, Haley; Dinger, John; Giakas, Alec; Horan, Michael Less

Spine. 49(17):1203-1209, September 1, 2024.

Lumbar Lordosis Redistribution and Segmental Correction in Adult Spinal Deformity: Does it Matter?

Diebo, Bassel G.; Balmaceno-Criss, Mariah; Lafage, Renaud; More

Diebo, Bassel G.; Balmaceno-Criss, Mariah; Lafage, Renaud; Daher, Mohammad; Singh, Manjot; Hamilton, D. Kojo; Smith, Justin S.; Eastlack, Robert K.; Fessler, Richard; Gum, Jeffrey L.; Gupta, Munish C.; Hostin, Richard; Kebaish, Khaled M.; Lewis, Stephen; Line, Breton G.; Nunley, Pierce D.; Mundis, Gregory M.; Passias, Peter G.; Protopsaltis, Themistocles S.; Turner, Jay; Buell, Thomas; Scheer, Justin K.; Mullin, Jeffery; Soroceanu, Alex; Ames, Christopher P.; Bess, Shay; Shaffrey, Christopher I.; Lenke, Lawrence G.; Schwab, Frank J.; Lafage, Virginie; Burton, Douglas C.; Daniels, Alan H.; on behalf of the International Spine Study Group (ISSG) Less

Spine. 49(17):1187-1194, September 1, 2024.

Novel Calcium Phosphate Promotes Interbody Bony Fusion in a Porcine Anterior Cervical Discectomy and Fusion Model

Östman, Maria; Försth, Peter; Hedenqvist, Patricia; More

Östman, Maria; Försth, Peter; Hedenqvist, Patricia; Engqvist, Håkan; Marcelino, Leticia; Ytrehus, Bjørnar; Hulsart-Billström, Gry; Pujari-Palmer, Michael; Öhman-Mägi, Caroline; Höglund, Odd; Forterre, Franck Less

Spine. 49(17):1179-1186, September 1, 2024.

Primary Pelvic Anteversion: Definition, Relevance, and History After Surgery for Adult Spine Deformity

Baroncini, Alice; Boissiere, Louis; Yilgor, Caglar; More

Baroncini, Alice; Boissiere, Louis; Yilgor, Caglar; Larrieu, Daniel; Alanay, Ahmet; Pellisé, Ferran; Kleinstueck, Frank; Pizones, Javier; Charles, Yann Philippe; Roscop, Cecile; Bourghli, Anouar; Obeid, Ibrahim; On behalf of the European Spine Study Group (ESSG) Less

Spine. 49(16):1107-1115, August 15, 2024.

AI Summary This study aimed to identify the best definition of primary anteverted pelvis (AP) in adult spine deformity (ASD) and determine if it requires surgical correction. Researchers compared four AP definitions using data from 1163 ASD patients and found the Relative Pelvic Version (RPV) method to be the most suitable. A subgroup analysis of 410 operated patients with a two-year follow-up showed that those who maintained AP had similar radiographic and clinical outcomes (ODI, SF-36) to those with normoverted/retroverted pelvis post-surgery. The study concludes that primary AP, often seen in young adults with idiopathic scoliosis, is not a pathologic condition and does not necessitate surgical correction

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Surgical Failure and Revision Strategy for Atlantoaxial Dislocation: A Retrospective Study of 109 Cases

Ma, Xiangyang; Zou, Xiaobao; Chen, Zexing; More

Ma, Xiangyang; Zou, Xiaobao; Chen, Zexing; Yang, Haozhi; Chen, Junlin; Ma, Rencai; Fu, Suochao; Xia, Hong Less

Spine. 49(16):1116-1124, August 15, 2024.

AI Summary This retrospective study aimed to classify surgical failures after atlantoaxial dislocation surgery, propose revision strategies, and assess the outcomes of these revisions. Among 109 cases, failures were categorized into three types: nonreduction with nonfusion (NR-NF, 73 cases), nonreduction with fusion (NR-F, 19 cases), and reduction with nonfusion (R-NF, 17 cases). Revision surgeries included anterior, posterior, and anteroposterior approaches. Post-revision, all cases achieved complete decompression, 89 had anatomical reduction, 77 showed significant improvement in Japanese Orthopaedic Association scores, and 86 achieved fusion. The study highlights that NR-NF is the most common failure type and emphasizes the importance of targeted revision strategies to improve surgical outcomes

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Natural History of Intradiscal Vacuum Phenomenon and its Role in Advanced Disc Degeneration

Cawley, Derek T.; Simpkin, Andrew; Abrahim, Elizabeth; More

Cawley, Derek T.; Simpkin, Andrew; Abrahim, Elizabeth; Doyle, Thomas; Elsheikh, Nada; Fallon, John; Habash, Mohammed; Phua, Rou Jiing; Langille, Jaimie; Matini, Elvis; McNamee, Conor; Mohamed, Fayhaa; Nic Gabhann, Cliona; Noorani, Ali; Oh, Jieun; O’Reilly, Padraig; O’Sullivan, David; Devitt, Aiden Less

Spine. 49(16):1130-1136, August 15, 2024.

AI Summary This study used serial CT scans to observe the lumbar spine in people over 60 years old to understand the natural history of the intradiscal vacuum phenomenon (IDVP) and its role in disc degeneration. The study included 60 patients (29 males, 31 females, average age 68.9 years) with at least one level of IDVP, followed up after an average of 10.3 years. Results showed that IDVP persisted in most cases (45 levels), with some progressing (26), regressing (8), or fusing (3). Additionally, 62% of levels developed IDVP at another level. Disc height decreased with increased IDVP severity. Back pain was recorded in 31 patients but did not significantly worsen with increased IDVP severity or additional level involvement. The study concludes that IDVP generally persists without significant progression to autofusion in advanced disc degeneration

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Limited Improvement With Minimally Invasive Lumbar Decompression Alone for Degenerative Scoliosis With Cobb Angle Over 20°: The Impact of Decompression Location

Asada, Tomoyuki; Simon, Chad Z.; Singh, Nishtha; More

Asada, Tomoyuki; Simon, Chad Z.; Singh, Nishtha; Tuma, Olivia; Subramanian, Tejas; Araghi, Kasra; Lu, Amy Z.; Mai, Eric; Kim, Yeo Eun; Allen, Myles R.J.; Korsun, Maximilian; Zhang, Joshua; Kwas, Cole; Singh, Sumedha; Dowdell, James; Sheha, Evan D.; Qureshi, Sheeraz A.; Iyer, Sravisht Less

Spine. 49(15):1037-1045, August 1, 2024.

Zhao, Amy Y.; Agarwal, Amil R.; Durand, Wesley M.; More

Zhao, Amy Y.; Agarwal, Amil R.; Durand, Wesley M.; Raad, Micheal; Seibold, B. Tanner; Thakkar, Savyasachi C.; Jain, Amit Less

Spine. 49(15):1046-1051, August 1, 2024.

The Biomechanics of the Transpedicular Endoscopic Approach

Meisterhans, Michel; Hagel, Vincent; Spirig, José M.; More

Meisterhans, Michel; Hagel, Vincent; Spirig, José M.; Fasser, Marie-Rosa; Farshad, Mazda; Widmer, Jonas Less

Spine. 49(15):1052-1058, August 1, 2024.

Examining the Role of Paraspinal Musculature in Postoperative Disability After Lumbar Fusion Surgery for Degenerative Spondylolisthesis

Schönnagel, Lukas; Guven, Ali E.; Camino-Willhuber, Gaston; More

Schönnagel, Lukas; Guven, Ali E.; Camino-Willhuber, Gaston; Caffard, Thomas; Tani, Soji; Zhu, Jiaqi; Haffer, Henryk; Muellner, Maximilian; Zadeh, Arman; Sanchez, Leonardo A.; Shue, Jennifer; Duculan, Roland; Schömig, Friederike; Sama, Andrew A.; Cammisa, Frank P.; Girardi, Federico P.; Mancuso, Carol A.; Hughes, Alexander P. Less

Spine. 49(14):997-1003, July 15, 2024.

Characteristics of Spinal Morphology According to the Global Alignment and Proportion (GAP) Score in a Diverse, Asymptomatic Cohort: Multi-Ethnic Alignment Normative Study

Shen, Yong; Sardar, Zeeshan M.; Malka, Matan; More

Shen, Yong; Sardar, Zeeshan M.; Malka, Matan; Reyes, Justin; Katiyar, Prerana; Hassan, Fthimnir; Le Huec, Jean-Charles; Bourret, Stephane; Hasegawa, Kazuhiro; Wong, Hee Kit; Liu, Gabriel; Dennis Hey, Hwee Weng; Riahi, Hend; Kelly, Michael; Lombardi, Joseph M.; Lenke, Lawrence G.; Multi-Ethnic Alignment Normative Study Group Less

Spine. 49(14):979-989, July 15, 2024.

Preoperative Oswestry Disability Index Should not be Utilized to Determine Surgical Eligibility for Patients Requiring Lumbar Fusion for Degenerative Lumbar Spine Disease

Issa, Tariq Z.; Haider, Ameer A.; Lambrechts, Mark J.; More

Issa, Tariq Z.; Haider, Ameer A.; Lambrechts, Mark J.; Sherman, Matthew B.; Canseco, Jose A.; Vaccaro, Alexander R.; Schroeder, Gregory D.; Kepler, Christopher K.; Hilibrand, Alan S. Less

Spine. 49(14):965-972, July 15, 2024.

Adding Vertebral Bone Quality to the Fusion Risk Score: Does It Improve Predictions of Postoperative Complications?

Ramos, Omar; Razzouk, Jacob; Beauchamp, Eduardo; More

Ramos, Omar; Razzouk, Jacob; Beauchamp, Eduardo; Mueller, Benjamin; Shafa, Eiman; Mehbod, Amir A.; Cheng, Wayne; Danisa, Olumide; Carlson, Bayard C. Less

Spine. 49(13):916-922, July 1, 2024.

Does Operative Level Impact Dysphagia Severity After Anterior Cervical Discectomy and Fusion?: A Multicenter Prospective Analysis

Paziuk, Taylor; Mazmudar, Aditya S.; Issa, Tariq Z.; More

Paziuk, Taylor; Mazmudar, Aditya S.; Issa, Tariq Z.; Henry, Tyler W.; Patel, Alpesh A.; Hilibrand, Alan S.; Schroeder, Gregory D.; Kepler, Christopher K.; Vaccaro, Alexander R.; Rihn, Jeffrey A.; Brodke, Darrel S.; Bisson, Erica F.; Karamian, Brian A. Less

Spine. 49(13):909-915, July 1, 2024.

Critical Analysis of Radiographic and Patient-Reported Outcomes Following Anterior/Posterior Staged Versus Same-Day Surgery in Patients Undergoing Identical Corrective Surgery for Adult Spinal Deformity

Passias, Peter G.; Ahmad, Waleed; Tretiakov, Peter S.; More

Passias, Peter G.; Ahmad, Waleed; Tretiakov, Peter S.; Lafage, Renaud; Lafage, Virginie; Schoenfeld, Andrew J.; Line, Breton; Daniels, Alan; Mir, Jamshaid M.; Gupta, Munish; Mundis, Gregory; Eastlack, Robert; Nunley, Pierce; Hamilton, D. Kojo; Hostin, Richard; Hart, Robert; Burton, Douglas C.; Shaffrey, Christopher; Schwab, Frank; Ames, Christopher; Smith, Justin S.; Bess, Shay; Klineberg, Eric O.; on behalf of the International Spine Study Group Less

Spine. 49(13):893-901, July 1, 2024.

The Inhibitory Effect of NSAIDs and Opioids on Spinal Fusion: An Animal Model

Lambrechts, Mark J.; D’Antonio, Nicholas D.; Heard, Jeremy C.; More

Lambrechts, Mark J.; D’Antonio, Nicholas D.; Heard, Jeremy C.; Yalla, Goutham; Karamian, Brian A.; Markova, Dessislava Z.; Kepler, Christopher K. Less

Spine. 49(12):821-828, June 15, 2024.

Complication Rates Following Adult Spinal Deformity Surgery: Evaluation of the Category of Complication and Chronology

Lafage, Renaud; Bass, R. Daniel; Klineberg, Eric; More

Lafage, Renaud; Bass, R. Daniel; Klineberg, Eric; Smith, Justin S.; Bess, Shay; Shaffrey, Christopher; Burton, Douglas C.; Kim, Han Jo; Eastlack, Robert; Mundis, Gregory Jr; Ames, Christopher P.; Passias, Peter G.; Gupta, Munish; Hostin, Richard; Hamilton, Kojo; Schwab, Frank; Lafage, Virginie; on behalf of the International Spine Study Group Less

Spine. 49(12):829-839, June 15, 2024.

Lumbar Decompression With and Without Fusion for Lumbar Stenosis With Spondylolisthesis: A Cost Utility Analysis

Sastry, Rahul A.; Levy, Joseph F.; Chen, Jia-Shu; More

Sastry, Rahul A.; Levy, Joseph F.; Chen, Jia-Shu; Weil, Robert J.; Oyelese, Adetokunbo A.; Fridley, Jared S.; Gokaslan, Ziya L. Less

Spine. 49(12):847-856, June 15, 2024.

Health Care Costs Following Anterior Cervical Discectomy and Fusion or Cervical Disc Arthroplasty

Nin, Darren Z.; Chen, Ya-Wen; Kim, David H.; More

Nin, Darren Z.; Chen, Ya-Wen; Kim, David H.; Niu, Ruijia; Powers, Andrew; Chang, David C.; Hwang, Raymond W. Less

Spine. 49(8):530-535, April 15, 2024.

Comparison of Four Nutritional Screening Tools for Predicting Postoperative Adverse Events Following Degenerative Spinal Deformity Surgery

Wang, Shuai-Kang; Li, Jun; Wang, Peng; More

Wang, Shuai-Kang; Li, Jun; Wang, Peng; Li, Xiang-Yu; Kong, Chao; Ma, Jin; Lu, Shi-Bao Less

Spine. 49(8):536-546, April 15, 2024.

Response to Preoperative Steroid Injections Predicts Surgical Outcomes in Patients Undergoing Fusion for Isthmic Spondylolisthesis

Turtle, Joel; Randell, Zane; Karamian, Brian; More

Turtle, Joel; Randell, Zane; Karamian, Brian; Spiker, William Ryan; Lawrence, Brandon; Brodke, Darrel; Spina, Nicholas Less

Spine. 48(13):914-919, July 1, 2023.

Spine Surgeon Assessments of Patient Psychological Distress are Inaccurate and Bias Treatment Recommendations

Moon, Andrew S.; Menendez, Mariano E.; Moverman, Michael A.; More

Moon, Andrew S.; Menendez, Mariano E.; Moverman, Michael A.; Proal, Joshua D.; Kim, David H.; Ohaegbulam, Chima; Kwon, Brian Less

Spine. 48(13):908-913, July 1, 2023.

Singh, Aman; Blixt, Simon; Edström, Erik; More

Singh, Aman; Blixt, Simon; Edström, Erik; Elmi-Terander, Adrian; Gerdhem, Paul Less

Spine. 48(12):853-858, June 15, 2023.

Does Adult Spinal Deformity Affect Cardiac Function? A Prospective Perioperative Study

Mihara, Yuki; Saitoh, Takeji; Hasegawa, Tomohiko; More

Mihara, Yuki; Saitoh, Takeji; Hasegawa, Tomohiko; Yamato, Yu; Yoshida, Go; Banno, Tomohiro; Arima, Hideyuki; Oe, Shin; Ide, Koichiro; Yamada, Tomohiro; Kurosu, Kenta; Nakai, Keiichi; Matsuyama, Yukihiro Less

Spine. 48(12):832-842, June 15, 2023.

Single Nucleotide Polymorphisms and Adolescent Idiopathic Scoliosis: A Systematic Review and Meta-Analysis of the Literature

AlMekkawi, Ahmad K.; Caruso, James P.; El Ahmadieh, Tarek Y.; More

AlMekkawi, Ahmad K.; Caruso, James P.; El Ahmadieh, Tarek Y.; Palmisciano, Paolo; Aljardali, Marwa W.; Derian, Armen G.; Al Tamimi, Mazin; Bagley, Carlos A.; Aoun, Salah G. Less

Spine. 48(10):695-701, May 15, 2023.

Postoperative Dural Sac Cross-Sectional Area as an Association for Outcome After Surgery for Lumbar Spinal Stenosis: Clinical and Radiological Results From the NORDSTEN-Spinal Stenosis Trial

Hermansen, Erland; Myklebust, Tor Å.; Weber, Clemens; More

Hermansen, Erland; Myklebust, Tor Å.; Weber, Clemens; Brisby, Helena; Austevoll, Ivar M.; Hellum, Christian; Storheim, Kjersti; Aaen, Jørn; Banitalebi, Hasan; Brox, Jens I.; Grundnes, Oliver; Rekeland, Frode; Solberg, Tore; Franssen, Eric; Indrekvam, Kari Less

Spine. 48(10):688-694, May 15, 2023.

The Effect of Local Administration of Vancomycin Suspended in Fibrin Glue for Prevention of Surgical Site Infection After Spinal Instrumentation: Comparison by Probability of Treatment Weighting Model

Higashi, Takayuki; Kobayashi, Naomi; Ide, Manabu; More

Higashi, Takayuki; Kobayashi, Naomi; Ide, Manabu; Uchino, Yosuke; Inoue, Tetsuhiko; Inaba, Yutaka Less

Spine. 48(6):384-390, March 15, 2023.

Deterioration After Surgery for Degenerative Cervical Myelopathy: An Observational Study From the Canadian Spine Outcomes and Research Network

Evaniew, Nathan; Burger, Lukas D.; Dea, Nicolas; More

Evaniew, Nathan; Burger, Lukas D.; Dea, Nicolas; Cadotte, David W.; Bailey, Christopher S.; Christie, Sean D.; Fisher, Charles G.; Rampersaud, Y Raja; Paquet, Jérôme; Singh, Supriya; Weber, Michael H.; Attabib, Najmedden; Johnson, Michael G.; Manson, Neil; Phan, Philippe; Nataraj, Andrew; Wilson, Jefferson R.; Hall, Hamilton; McIntosh, Greg; Jacobs, W. Bradley; On behalf of the Canadian Spine Outcomes and Research Network (CSORN) Less

Spine. 48(5):310-320, March 1, 2023.

Management of Anticoagulation/Antiplatelet Medication and Venous Thromboembolism Prophylaxis in Elective Spine Surgery: Concise Clinical Recommendations Based on a Modified Delphi Process

Zuckerman, Scott L.; Berven, Sigurd; Streiff, Michael B.; More

Zuckerman, Scott L.; Berven, Sigurd; Streiff, Michael B.; Kerolus, Mena; Buchanan, Ian A.; Ha, Alex; Bonfield, Christopher M.; Buchholz, Avery L.; Buchowski, Jacob M.; Burch, Shane; Devin, Clinton J.; Dimar, John R.; Gum, Jeffrey L.; Good, Christopher; Kim, Han Jo; Kim, Jun S.; Lombardi, Joseph M.; Mandigo, Christopher E.; Bydon, Mohamad; Oppenlander, Mark E.; Polly, David W. Jr; Poulter, Gregory; Shah, Suken A.; Singh, Kern; Than, Khoi D.; Spyropoulos, Alex C.; Kaatz, Scott; Jain, Amit; Schutzer, Richard W.; Wang, Tina Z.; Mazique, Derek C.; Lenke, Lawrence G.; Lehman, Ronald A. Less

Spine. 48(5):301-309, March 1, 2023.

A Propensity Score–matched Analysis of Clinical Outcomes Between Single-level and Multilevel Intervertebral Decompression for Cervical Radiculopathy

Oshina, Masahito; Kawamura, Naohiro; Hara, Nobuhiro; More

Oshina, Masahito; Kawamura, Naohiro; Hara, Nobuhiro; Higashikawa, Akiro; Ono, Takashi; Takeshita, Yujiro; Azuma, Seiichi; Fukushima, Masayoshi; Iwai, Hiroki; Kaneko, Takeshi; Inanami, Hirohiko; Oshima, Yasushi Less

Spine. 48(4):247-252, February 15, 2023.

Leister, Iris; Haider, Thomas; Vogel, Matthias; More

Leister, Iris; Haider, Thomas; Vogel, Matthias; Vastmans, Jan; Langthaler, Patrick; Mattiassich, Georg; Christ, Alexandra; Etschmaier, Martin; Eijkenboom, Alexander; Burghuber, Julia; Kindermann, Harald; Mach, Orpheus; Maier, Doris; Högel, Florian Less

Spine. 48(3):164-171, February 1, 2023.

Are Octogenarians at Higher Risk of Complications After Elective Lumbar Spinal Fusion Surgery? Analysis of a Cohort of 7880 Patients From the Kaiser Permanente Spine Registry

Kuo, Calvin C.; Royse, Kathryn E.; Prentice, Heather A.; More

Kuo, Calvin C.; Royse, Kathryn E.; Prentice, Heather A.; Harris, Jessica E.; Guppy, Kern H. Less

Spine. 47(24):1719-1727, December 15, 2022.

Lower Prevalence and Severity of Degenerative Changes in the Lumbar Spine in Elderly Hong Kong Chinese Compared With Age-Matched Italian Caucasian Women

So, Tiffany Y.; Diacinti, Davide; Leung, Jason C.S.; More

So, Tiffany Y.; Diacinti, Davide; Leung, Jason C.S.; Iannacone, Antonio; Kripa, Endi; Kwok, Timothy C.Y.; Diacinti, Daniele; Wang, Yi Xiang J. Less

Spine. 47(24):1710-1718, December 15, 2022.

Comparison of Deep Learning and Classical Machine Learning Algorithms to Predict Postoperative Outcomes for Anterior Cervical Discectomy and Fusion Procedures With State-of-the-art Performance

Rodrigues, Adrian J.; Schonfeld, Ethan; Varshneya, Kunal; More

Rodrigues, Adrian J.; Schonfeld, Ethan; Varshneya, Kunal; Stienen, Martin N.; Staartjes, Victor E.; Jin, Michael C.; Veeravagu, Anand Less

Spine. 47(23):1637-1644, December 1, 2022.

Sex-based Difference in Response to Recombinant Human Bone Morphogenetic Protein-2 in a Rat Posterolateral Fusion Model

Foley, James P.; Fred, Elianna J.; Minardi, Silvia; More

Foley, James P.; Fred, Elianna J.; Minardi, Silvia; Yamaguchi, Jonathan T.; Greene, Allison C.; Furman, Andrew A.; Lyons, Joseph G.; Paul, Jonathan T.; Nandurkar, Tejas S.; Blank, Kenneth R.; Havey, Robert M.; Muriuki, Muturi; Patwardhan, Avinash G.; Hsu, Wellington K.; Stock, Stuart R.; Hsu, Erin L. Less

Spine. 47(23):1627-1636, December 1, 2022.

Postoperative Sagittal Balance Has Only a Limited Role in the Development of Adjacent Segment Disease After Lumbar Spine Fusion for Degenerative Lumbar Spine Disorders: A Subanalysis of the 10-year Follow-up Study

Toivonen, Leevi A.; Mäntymäki, Heikki; Häkkinen, Arja; More

Toivonen, Leevi A.; Mäntymäki, Heikki; Häkkinen, Arja; Kautiainen, Hannu; Neva, Marko H. Less

Spine. 47(19):1357-1361, October 1, 2022.

Ultrasound-guided Cervical Retro-laminar Block for Cervical Radicular Pain: A Comparative Analysis

Khashan, Morsi; de Santiago, Jesus; Pardo, Itai; More

Khashan, Morsi; de Santiago, Jesus; Pardo, Itai; Regev, Gilad; Ophir, Dror; Salame, Khalil; Lidar, Zvi; Brill, Silviu; Hochberg, Uri Less

Spine. 47(19):1351-1356, October 1, 2022.

Robotics Reduces Radiation Exposure in Minimally Invasive Lumbar Fusion Compared With Navigation

Shahi, Pratyush; Vaishnav, Avani; Araghi, Kasra; More

Shahi, Pratyush; Vaishnav, Avani; Araghi, Kasra; Shinn, Daniel; Song, Junho; Dalal, Sidhant; Melissaridou, Dimitra; Mai, Eric; Dupont, Marcel; Sheha, Evan; Dowdell, James; Iyer, Sravisht; Qureshi, Sheeraz A. Less

Spine. 47(18):1279-1286, September 15, 2022.

Postoperative Pain Management Following Orthopedic Spine Procedures and Consequent Acute Opioid Poisoning: An Analysis of New York State From 2009 to 2018

Kim, Kang Woo; Brodeur, Peter G.; Mullen, Marguerite A.; More

Kim, Kang Woo; Brodeur, Peter G.; Mullen, Marguerite A.; Gil, Joseph A.; Cruz, Aristides I. Jr Less

Spine. 47(18):1270-1278, September 15, 2022.

Telemedicine Visits Can Generate Highly Accurate Diagnoses and Surgical Plans for Spine Patients

Bovonratwet, Patawut; Song, Junho; Kim, Yeo Eun; More

Bovonratwet, Patawut; Song, Junho; Kim, Yeo Eun; Shinn, Daniel; Morse, Kyle W.; Dowdell, James E.; Huang, Russel C.; Albert, Todd J.; Sandhu, Harvinder S.; Qureshi, Sheeraz A.; Iyer, Sravisht Less

Spine. 47(17):1194-1202, September 1, 2022.

Factors Causing Delay in Discharge in Patients Eligible for Ambulatory Lumbar Fusion Surgery

Shahi, Pratyush; Vaishnav, Avani S.; Melissaridou, Dimitra; More

Shahi, Pratyush; Vaishnav, Avani S.; Melissaridou, Dimitra; Sivaganesan, Ahilan; Sarmiento, Jose M.; Urakawa, Hikari; Araghi, Kasra; Shinn, Daniel J.; Song, Junho; Dalal, Sidhant S.; Iyer, Sravisht; Sheha, Evan D.; Dowdell, James E.; Qureshi, Sheeraz A. Less

Spine. 47(16):1137-1144, August 15, 2022.

Preoperative Patient-reported Outcomes are not Associated With Sagittal and Spinopelvic Alignment in Degenerative Lumbar Spondylolisthesis

Karim, S. Mohammed; Fisher, Charles; Glennie, Andrew; More

Karim, S. Mohammed; Fisher, Charles; Glennie, Andrew; Rampersaud, Raja; Street, John; Dvorak, Marcel; Paquette, Scott; Kwon, Brian K.; Charest-Morin, Raphaele; Ailon, Tamir; Manson, Neil; Abraham, Edward; Thomas, Ken; Urquhart, Jennifer; Bailey, Christopher S. Less

Spine. 47(16):1128-1136, August 15, 2022.

Clinical Outcomes at One-year Follow-up for Patients With Surgical Site Infection After Spinal Fusion

Karamian, Brian A.; Mao, Jennifer; Toci, Gregory R.; More

Karamian, Brian A.; Mao, Jennifer; Toci, Gregory R.; Lambrechts, Mark J.; Canseco, Jose A.; Qureshi, Mahir A.; Silveri, Olivia; Minetos, Paul D.; Jallo, Jack I.; Prasad, Srinivas; Heller, Joshua E.; Sharan, Ashwini D.; Harrop, James S.; Woods, Barrett I.; Kaye, Ian David; Hilibrand, Alan; Kepler, Christopher K.; Vaccaro, Alexander R.; Schroeder, Gregory D. Less

Spine. 47(15):1055-1061, August 1, 2022.

Predictors of Dysphagia After Anterior Cervical Discectomy and Fusion: A Prospective Multicenter Study

Nguyen, Sarah; Sherrod, Brandon A.; Paziuk, Taylor M.; More

Nguyen, Sarah; Sherrod, Brandon A.; Paziuk, Taylor M.; Rihn, Jeffrey A.; Patel, Alpesh A.; Brodke, Darrel S.; Bisson, Erica F. Less

SPINE. 47(12):859-864, June 15, 2022.

In Brief:

In a prospective multicenter study of 170 patients using the validated EAT-10 index to measure dysphagia after ACDF, rates of dysphagia increased to 45.3% at 2 weeks postoperatively but decreased to 15.3% at 24 weeks. Smoking and baseline dysphagia were independently associated with prolonged dysphagia at 24 weeks after ACDF.

The Relation of Patient Expectations, Satisfaction, and Outcome in Surgery of the Cervical Spine: A Prospective Study

Krauss, Philipp; Reinartz, Feline; Sonnleitner, Clara; More

Krauss, Philipp; Reinartz, Feline; Sonnleitner, Clara; Vazan, Martin; Ringel, Florian; Meyer, Bernhard; Meyer, Hanno S. Less

SPINE. 47(12):849-858, June 15, 2022.

In Brief:

This prospective observational study on patients undergoing cervical spine stabilization investigated the relationship between patient expectations, satisfaction and outcome scores. Expectations and satisfaction rates were high. Satisfaction correlated positively with outcome scores, especially with pain reduction in different degenerative diseases (radiculopathy, myelopathy). NDI is a possible screening tool for dissatisfaction.

Association Between Sleep Disturbance and Low Back Pain: A 3-Year Longitudinal Study After the Great East Japan Earthquake

Yabe, Yutaka; Hagiwara, Yoshihiro; Sekiguchi, Takuya; More

Yabe, Yutaka; Hagiwara, Yoshihiro; Sekiguchi, Takuya; Sugawara, Yumi; Tsuchiya, Masahiro; Yoshida, Shinichirou; Tsuji, Ichiro Less

SPINE. 47(4):361-368, February 15, 2022.

In Brief:

A 3-year longitudinal study among people living in disaster-stricken areas showed that sleep disturbance is associated with low back pain, and the effect is stronger with an increase in the duration and frequency of sleep disturbance.

Magnetically Controlled Growing Rods (MCGR) Versus Single Posterior Spinal Fusion (PSF) Versus Vertebral Body Tether (VBT) in Older Early Onset Scoliosis (EOS) Patients: How Do Early Outcomes Compare?

Mackey, Catherine; Hanstein, Regina; Lo, Yungtai; More

Mackey, Catherine; Hanstein, Regina; Lo, Yungtai; Vaughan, Majella; St. Hilaire, Tricia; Luhmann, Scott J.; Vitale, Michael G.; Glotzbecker, Michael P.; Samdani, Amer; Parent, Stefan; Gomez, Jaime A. Less

SPINE. 47(4):295-302, February 15, 2022.

In Brief:

Retrospective review of data from a multicenter spine registry showed that in idiopathic 8- to 11-year-old early onset scoliosis patients, posterior spinal fusion (PSF), vertebral body tethers (VBT), and magnetically controlled growing rods control scoliosis effectively and lead to similar spinal height gain. PSF and VBT patients reduced the hazard of unplanned surgeries and showed improvements in quality of life.

In vivo 3-Dimensional Kinematics Study of the Healthy Cervical Spine Based on CBCT Combined with 3D-3D Registration Technology

Tang, Benyu; Yao, Haoqun; Wang, Shaobai; More

Tang, Benyu; Yao, Haoqun; Wang, Shaobai; Zhong, Yanlong; Cao, Kai; Wan, Zongmiao Less

SPINE. 46(24):E1301-E1310, December 15, 2021.

In Brief:

Cone beam computed tomography combined with 3D-3D registration technique was used to accurately describe the in vivo three-dimensional features of cervical segmental motion for the first time. The measurement results provide necessary biomechanical data support for the diagnosis and treatment of cervical diseases.

Primary and Revision Anterior Cervical Discectomy and Fusion: A Study of Otolaryngologic Outcomes in a Large Cohort

Wong, Michele; Williams, Nicholas; Kacker, Ashutosh

Wong, Michele; Williams, Nicholas; Kacker, Ashutosh Less

SPINE. 46(24):1677-1682, December 15, 2021.

In Brief:

Electronic medical records of 718 adults who underwent anterior cervical discectomy and fusion (ACDF) with predicted difficult surgical site exposure were reviewed. Prior thyroidectomy and number of spinal levels addressed during ACDF were identified as risk factors for postoperative otolaryngologic complications whereas revision ACDF was not associated with increased odds.

Machine Learning Approach in Predicting Clinically Significant Improvements After Surgery in Patients with Cervical Ossification of the Posterior Longitudinal Ligament

Maki, Satoshi; Furuya, Takeo; Yoshii, Toshitaka; More

Maki, Satoshi; Furuya, Takeo; Yoshii, Toshitaka; Egawa, Satoru; Sakai, Kenichiro; Kusano, Kazuo; Nakagawa, Yukihiro; Hirai, Takashi; Wada, Kanichiro; Katsumi, Keiichi; Fujii, Kengo; Kimura, Atsushi; Nagoshi, Narihito; Kanchiku, Tsukasa; Nagamoto, Yukitaka; Oshima, Yasushi; Ando, Kei; Takahata, Masahiko; Mori, Kanji; Nakajima, Hideaki; Murata, Kazuma; Matsunaga, Shunji; Kaito, Takashi; Yamada, Kei; Kobayashi, Sho; Kato, Satoshi; Ohba, Tetsuro; Inami, Satoshi; Fujibayashi, Shunsuke; Katoh, Hiroyuki; Kanno, Haruo; Imagama, Shiro; Koda, Masao; Kawaguchi, Yoshiharu; Takeshita, Katsushi; Matsumoto, Morio; Ohtori, Seiji; Yamazaki, Masashi; Okawa, Atsushi Less

SPINE. 46(24):1683-1689, December 15, 2021.

In Brief:

The current study shown that constructing a prognostic model for surgical outcomes in patients with cervical ossification of the posterior longitudinal ligament (OPLL) using machine learning (ML) is feasible. The ML-based models showed moderate predictive ability of surgical outcomes in patients with OPLL based on demographic data.

Pseudarthrosis Following Lumbar and Lumbosacral Fusion Using the Antepsoas Technique

Tannoury, Chadi; Bhale, Rahul; Vora, Molly; More

Tannoury, Chadi; Bhale, Rahul; Vora, Molly; Saade, Aziz; Kortbawi, Rabih; Orlando, Giuseppe; Das, Avilash; Tannoury, Tony Less

SPINE. 46(24):1690-1695, December 15, 2021.

In Brief:

Pseudarthrosis is a feared complication following spinal fusions. In 220 patients treated with minimally invasive antepsoas-lumbar fusions, arthrodesis was evaluated using follow-up computed tomography scans. Successful fusion was noted in 96.4% of operated patients and 98.3% of the fused levels. Nonetheless, smoking history, multilevel fusions, and surgery at L5-S1 remain considerable risk factors.

Lumbar Thecal Sac Dimensions and Axial Spinal Cord Areas on Magnetic Resosnace Imaging in 626 Healthy Subjects

Nakashima, Hiroaki; Ito, Keigo; Katayama, Yoshito; More

Nakashima, Hiroaki; Ito, Keigo; Katayama, Yoshito; Matsumoto, Tomohiro; Tsushima, Mikito; Ando, Kei; Kobayashi, Kazuyoshi; Machino, Masaaki; Imagama, Shiro Less

SPINE. 46(24):E1327-E1333, December 15, 2021.

In Brief:

The thecal sac and spinal cord area were investigated in 629 healthy volunteers. The thecal sac area was reduced in older age group from T12/L1 to L4/5, and the area at L4-5 was 80% in subjects in their 70s. The morphological pattern of the stenosis varied by disc level.

Minimally Invasive Surgery for Neuromuscular Scoliosis: Results and Complications at a Minimal Follow-up of 5 Years

Gaume, Mathilde; Vergari, Claudio; Khouri, Nejib; More

Gaume, Mathilde; Vergari, Claudio; Khouri, Nejib; Skalli, Wafa; Glorion, Christophe; Miladi, Lotfi Less

SPINE. 46(24):1696-1704, December 15, 2021.

In Brief:

This minimally invasive fusionless technique for neuromuscular scoliosis showed a stable correction of spinal deformities and pelvic obliquity with a minimum of 5 years follow-up. The global complication rate was 31.3%. Arthrodesis was not required for all patient. This technique could be a good alternative to arthrodesis for neuromuscular scoliosis.

The Influence of Surgeon Experience and Subspeciality on the Reliability of the AO Spine Sacral Classification System

Karamian, Brian A.; Schroeder, Gregory D.; Levy, Hanna A.; More

Karamian, Brian A.; Schroeder, Gregory D.; Levy, Hanna A.; Canseco, Jose A.; Benneker, Lorin M.; Kandziora, Frank; Rajasekaran, Shanmuganathan; Öner, F. Cumhur; Schnake, Klaus J.; Kepler, Christopher K.; Vaccaro, Alexander R. Less

SPINE. 46(24):1705-1713, December 15, 2021.

In Brief:

The current study aimed to investigate the influence of the surgeons’ level of experience and subspeciality training on sacral fracture classification, demonstrating the AO Spine Sacral Classification System to be universally applicable among surgeons of various subspecialties and levels of experience with acceptable reliability, reproducibility, and accuracy.

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Initial Choice of Spinal Manipulative Therapy for Treatment of Chronic Low Back Pain Leads to Reduced Long-term Risk of Adverse Drug Events Among Older Medicare Beneficiaries

Whedon, James M.; Kizhakkeveettil, Anupama; Toler, Andrew WJ; More

Whedon, James M.; Kizhakkeveettil, Anupama; Toler, Andrew WJ; MacKenzie, Todd A.; Lurie, Jon D.; Hurwitz, Eric L.; Bezdjian, Serena; Bangash, Maria; Uptmor, Sarah; Rossi, Daniel; Haldeman, Scott Less

SPINE. 46(24):1714-1720, December 15, 2021.

In Brief:

Among older Medicare beneficiaries who initiated long-term care of chronic low back pain with opioid analgesic therapy, the adjusted rate of outpatient adverse drug events was more than 42 times higher as compared to those who initially chose spinal manipulative therapy (rate ratio 42.85, 95% CI 34.16–53.76, p < .0001).

Construct Validity and Item Response Theory Analysis of the PROMIS-29 v2.0 in Recipients of Lumbar Spine Surgery

Cook, Chad E.; Rethorn, Zachary D.; Chiarotto, Alessandro; More

Cook, Chad E.; Rethorn, Zachary D.; Chiarotto, Alessandro; Garcia, Alessandra N.; Gottfried, Oren Less

SPINE. 46(24):1721-1728, December 15, 2021.

In Brief:

The objectives of this study were to assess construct validity as well as reliability and discrimination of the PROMIS-29 v2.0 using item response theory (IRT). Findings yielded strong correlations between the PROMIS-29 v2.0 measure and legacy measures, whereas IRT analyses demonstrated adequate scale level difficulty, discrimination, and reliability.

Predictors of Nonelective Surgery for Spinal Metastases: Insights from a National Database

Khan, Hammad A.; Rabah, Nicholas M.; Chakravarthy, Vikram; More

Khan, Hammad A.; Rabah, Nicholas M.; Chakravarthy, Vikram; Tripathi, Raghav; Krishnaney, Ajit A. Less

SPINE. 46(24):E1334-E1342, December 15, 2021.

In Brief:

Non-elective surgery for spine tumors is associated with poor postoperative outcomes. Using a national all-payer database, we demonstrate substantial sociodemographic disparities in the receipt of non-elective versus elective surgery for spinal metastases and thereby elucidate patient populations that may serve as the focus of interventions to reduce disparities in care.

Mattie, Ryan; Brar, Nick; Tram, Jennifer T.; More

Mattie, Ryan; Brar, Nick; Tram, Jennifer T.; McCormick, Zachary L.; Beall, Douglas P.; Fox, Andrew; Saltychev, Mikhail Less

SPINE. 46(24):1729-1737, December 15, 2021.

In Brief:

Comparison of pain relief with vertebral augmentation for the treatment of cancer-related vertebral compression fractures through meta-analysis of randomized controlled trials. Vertebral augmentation provides an overall positive clinically and statistically significant improvement in pain relief for spinal compression fractures due to metastatic disease.

Diagnostic Accuracy of SSEP Changes During Lumbar Spine Surgery for Predicting Postoperative Neurological Deficit: A Systematic Review and Meta-Analysis

Chang, Robert; Reddy, Rajiv P.; Coutinho, Dominic V.; More

Chang, Robert; Reddy, Rajiv P.; Coutinho, Dominic V.; Chang, Yue-Fang; Anetakis, Katherine M.; Crammond, Donald J.; Balzer, Jeffrey R.; Thirumala, Parthasarathy D. Less

SPINE. 46(24):E1343-E1352, December 15, 2021.

In Brief:

This study evaluates the diagnostic accuracy of intraoperative SSEP changes during lumbar spine surgeries for predicting postoperative neurological deficits. Using systematic review and meta-analysis methods, a cohort of 5607 patients was analyzed. Three SSEP change subtypes—reversible, irreversible, and total signal loss—appear to indicate different risks for neurological deficits.

One Hundred Top Cited Articles in Cervical Myelopathy: A Bibliographic Analysis

Sinha, Amit; Dheerendra, Sujay; Munigangaiah, Sudarshan

Sinha, Amit; Dheerendra, Sujay; Munigangaiah, Sudarshan Less

SPINE. 46(24):E1353-E1358, December 15, 2021.

In Brief:

A bibliometric analysis of the top 100 most cited articles regarding cervical myelopathy was performed. Total citation count ranged from 121 to 541. The Spine Journal and the Journal of Neurosurgery published 66% of the articles. We provide a useful list of articles for those with an interest in this field.

Characteristics of Tc-MEP Waveforms in Spine Surgery for Patients with Severe Obesity

Kobayashi, Kazuyoshi; Ando, Kei; Yoshida, Go; More

Kobayashi, Kazuyoshi; Ando, Kei; Yoshida, Go; Ando, Muneharu; Kawabata, Shigenori; Yamada, Kei; Kanchiku, Tsukasa; Fujiwara, Yasushi; Taniguchi, Shinichirou; Iwasaki, Hiroshi; Shigematsu, Hideki; Tadokoro, Nobuaki; Takahashi, Masahito; Wada, Kanichiro; Yamamoto, Naoya; Funaba, Masahiro; Yasuda, Akimasa; Ushirozako, Hiroki; Hashimoto, Jun; Morito, Shinji; Takatani, Tsunenori; Tani, Toshikazu; Matsuyama, Yukihiro; Imagama, Shiro Less

SPINE. 46(24):1738-1747, December 15, 2021.

In Brief:

In transcranial motor evoked potential monitoring in spine surgery, the sensitivity and specificity of an amplitude decrease of ≥70% for prediction of neurologic complications were similar in severely obese patients (body mass index >35 kg/m2) and all other patients. However, cases with undetectable waveforms were more common among severely obese patients.

Postoperative Prescription of Low-dose Narcotics Yields Equivalent Pain Outcomes Compared to High-dose Narcotics in Opioid-naïve Patients Undergoing Spine Surgery

Mohanty, Sarthak; Shin, Max; Casper, David; More

Mohanty, Sarthak; Shin, Max; Casper, David; Saifi, Comron Less

SPINE. 46(24):1748-1757, December 15, 2021.

In Brief:

After adjusting for the heterogeneous spinal procedures, comorbidities, and perioperative pain, patients prescribed opioids <40 MME/day (equivalent to 5 tablets of 5 mg oxycodone/day) showed no difference in POD 30 pain (β: 0.095, P = 0.752) when compared to patients who received the highest dose analgesics (>80MME/day or 11 tablets of 5 mg oxycodone/day).

Anterior Cervical Discectomy and Fusion in the Ambulatory Surgery Center Versus Inpatient Setting: One-Year Cost-Utility Analysis

Monk, Steve H.; Hani, Ummey; Pfortmiller, Deborah; More

Monk, Steve H.; Hani, Ummey; Pfortmiller, Deborah; Smith, Mark D.; Kim, Paul K.; Bohl, Michael A.; Coric, Domagoj; Adamson, Tim E.; Holland, Christopher M.; McGirt, Matthew J. Less

Spine. 48(3):155-163, February 1, 2023.