INFLUENCE OF NON-H-2 GENETIC FACTORS ON SUCCESS... : Transplantation (original) (raw)

INFLUENCE OF NON-H-2 GENETIC FACTORS ON SUCCESS IN IMPLANTATION THERAPY OF W SERIES HEREDITARY ANEMIAS OF THE MOUSE

Elizabeth S. Russell
Seldon E. Bernstein

The severe macrocytic anemia of nonirradiatcd adult W/Wv mice be permanently cured by implantation of isogoneic normal hematopoietic cells. In one particularly favorable H-2 compatible allogencic combination the anemia of W/Wv adults has also been completely cured by injection of allogeneic normal (+/+) fetal liver cells. The extremely severe macrocytic anemia of WC/Re-W/W surviving adults was also greatly ameliorated by implantation of allogeneic normal WB/Re-+/+ marrow cells. Allogeneic skin grafts between these strains were rejected. Particular characteristics of W series anemias, which favor implantation and proliferation of injected normal blood-forming cells, may account for some of the cross-barrier successs obtained with these two allogeneic combinations. Similar and larger injections of normal fetal liver cells into adult anemic recipients had no beneficial effects in four other H-2 compatible allogencic combinations. Under the conditions of these experiments, successful implantation of normal blood-forming tissue must depend upon matching of H-S and several other sets of histocompatibility alleles. The histocompatibility barrier between WB/Re and WC/Re differs quantitatively or qualitatively from that involved in the four unsuccessful combinations. Between these two strains only, the histocompatibility difference prevents permanent acceptance of skin grafts but allows acceptance of blood-forming tissue. The failure of implant therapy of Sl/Sld mouse anemia, and relation between intrinsic nature of each hereditary anemia and the possibility of its cure by implantation of normal cells, are also discussed.