THE FAILURE OF THYMUS-DERIVED CELLS TO PRODUCE ANTIBODY : Transplantation (original) (raw)

ARTICLE: PDF Only

Davies, A. J. S.; Leuchars, E.; Wallis, V.; Makchant, R.; Elliott, E. V.

Chester Beatty Research Institute, Institute of Cancer Research, Royal Cancer Hospital, Fulham Road, London, England

Free

Abstract

The capacities of cells of thymus and bone marrow origin taken from radiation chimaeras to produce antibody during a secondary immune response have been tested in an in vivo transfer system. Although it could be shown that thymus-derived cells respond vigorously by mitosis to antigenic stimulation they were not capable of antibody production. By contrast bone marrow-derived cells did not in the first 3 days respond mitotically to antigenic stimulation but they were capable of limited antibody production. Most antibody was found when both cell populations were allowed to react to antigenic stimulation.