Regulation of ion transport by protein–protein interaction... : Current Opinion in Nephrology and Hypertension (original) (raw)
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The Hospital for Sick Children, Division of Respiratory Research and Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
Abstract
Protein-protein interaction via specific modular domains has been implicated in the regulation of many signalling pathways. Recently, such modules, in particular WW, Src homology-3 and PDZ domains, have been shown to regulate localization, clustering and function of several ion channels and transporters, including the epithelial Na+ channel, K+ channel and ionotropic neurotransmitter receptors.
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