Not all myofibroblasts are alike: revisiting the role of... : Current Opinion in Nephrology and Hypertension (original) (raw)
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revisiting the role of PDGF-A and PDGF-B using PDGF-targeted mice
Department of Medical Biochemistry, University of Göteburg, Gothenburg, Sweden
Abstract
Analyses of platelet-derived growth factor (PDGF) and PDGF-receptor knockout mice show that the development of specific subsets of smooth muscle cells (SMCs) depend on PDGF. Pericytes and mesangial cells failed to develop in PDGF-B deficient emtryos, whereas alveolar SMCs failed to develop in PDGP-A deficient embryos. The ontogeny of pericytes and alveolar SMCs suggests a common theme in the formation of PDGF-dependent SMCs, in which PDGF-receptor positive SMC progenitors spread from proximal to distal sites along PDGF-expressing epithelial, or endothelial, tubes.
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