Successful Cord Blood Transplantation for Sickle Cell... : Journal of Pediatric Hematology/Oncology (original) (raw)

Clinical And Laboratory Observations

Successful Cord Blood Transplantation for Sickle Cell Anemia From a Sibling Who Is Human Leukocyte Antigen-Identical: Implications for Comprehensive Care

Gore, Lia M.D.; Lane, Peter A. M.D.; Quinones, Ralph R. M.D.; Giller, Roger H. M.D.

From the Department of Pediatrics (L.G., P.A.L., R.R.Q., R.H.G.) and the Colorado Sickle Cell Treatment and Research Center (P.A.L.), University of Colorado School of Medicine, and The Children's Hospital, Denver, Colorado, U.S.A.

Submitted for publication September 27, 1999; accepted January 28, 2000.

Address correspondence and reprint requests to Roger H. Giller, M.D., The Children's Hospital, Hematology/Oncology/Bone Marrow Transplant, Box B-115, 1056 E. 19th Avenue, Denver, CO 80218. E-mail: [email protected].

Abstract

We report the successful transplantation of umbilical cord blood stem cells from a sibling who is human leukocyte antigen-matched to a child with sickle cell anemia. Conditioning was with busulfan, cyclophosphamide, and antithymocyte globulin. Time to neutrophil count >500/μL was 23 days and to platelet count >50,000/μL was 49 days. Full donor engraftment was achieved without graft-versus-host disease. This case demonstrates the potential usefulness of harvesting cord blood from full siblings of patients with sickle cell disease. Routine collection of umbilical cord blood from siblings should be considered for patients with sickle cell disease, and may increase acceptance and use of transplantation by families.