Th1 and Th2 cells : Current Opinion in Hematology (original) (raw)

Leukocytes

*Department of Immunology, University of Washington School of Medicine, Seattle, Washington, USA; †Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA

Correspondence to Richard A. Flavell, PhD, Immunobiology Section, Yale University School of Medicine, 310 Cedar Street, FMB 412, New Haven, CT 06120

Abstract

After activation, CD4 helper T (Th) cells differentiate into Th1 or Th2 effector subsets. These two types of cells produce distinct profiles of cytokines and regulate different immune responses. This review summarizes recent progress on different features of co-stimulatory regulation and chemokine-mediated homing of Th1 and Th2 cells. Transcription factors and signaling pathways that are selectively expressed or activated in Th1 and Th2 cells to regulate cytokine gene expression are discussed.