Liposomal Drug Delivery : Journal of Infusion Nursing (original) (raw)
Article
S. Dean Allison is Assistant Professor of Drug Delivery at the University of South Carolina College of Pharmacy. He has worked in the past with liposomes as models of cell membranes and for gene therapy.
Address correspondence to: College of Pharmacy, Coker Life Sciences Room 109, 715 Sumter Street, Columbia, SC 29208 (e-mail: [email protected]).
The author has no conflict of interest.
Liposomes are composed of phospholipids, the basic components of human cell walls. Liposome encapsulation improves a medication's bioavailability, which can extend treatment effects and reduce drug dosing. The therapeutic advantages of liposomal drug delivery, such as the ability of long-circulating liposomes to accumulate preferentially at disease sites, including tumors and sites of inflammation, are well recognized. In cases in which a single active has more than one liposome product available, formulation changes leading to differences in pharmacokinetics, toxicity, and clinical efficacy are described.
© Copyright 2007 by the Infusion Nurses Society