DISC1(Disrupted in Schizophrenia-1) is expressed in limbic... : NeuroReport (original) (raw)
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DISC1 (Disrupted in Schizophrenia-1) is expressed in limbic regions of the primate brain
Austin, Christopher P.*; Ma, Lei; Ky, Betty; Morris, Jill A.; Shughrue, Paul J.CA
Department of Neuroscience, Merck Research Laboratories, WP26A-3000, PO Box 4, 770 Sumneytown Pike, West Point, PA 19486, USA *Current address: National Human Genome Research Institute, NIH, Bldg 31, Rm 4B09, Bethesda, MD 20892
CACorresponding Author: [email protected]
Received 2 December 2002; accepted 6 February 2003
Abstract
Disrupted in Schizophrenia-1 (DISC1) was identified as truncated by a balanced translocation segregating with schizophrenia and other major mental illness in a large Scottish family. As a step in evaluating the function of DISC1 and its potential role in human schizophrenia, we have determined its regional expression in the primate brain by in situ hybridization. DISC1 expression is highly localized, with most prominent expression in the dentate gyrus of the hippocampus and lateral septum, and lower levels of expression in the cerebral cortex, amygdala, paraventricular hypothalamus, cerebellum, interpeduncular nucleus, and subthalamic nucleus. Given that many of these regions have been implicated in schizophrenia pathogenesis, these results suggest brain circuits through which DISC1 truncation may predispose to schizophrenia. NeuroReport 14:951–954 © 2003 Lippincott Williams & Wilkins.
© 2003 Lippincott Williams & Wilkins, Inc.