Pathophysiology of zonular diseases : Current Opinion in Ophthalmology (original) (raw)
Cataract surgery and lens implantation: Edited by Mark Packer, Drs Fine, Hoffman & Packer
Fondation Ophtalmologique Adolphe de Rothschild, Pediatric Ophthalmology Department, Paris, France
Correspondence to Pascal Dureau, MD, PhD, Fondation Ophtalmologique Adolphe de Rothschild, Pediatric Ophthalmology Department, 25–29 rue Manin, 75940 Paris Cedex 19, France Tel: +33 1 48 03 66 49; fax: +33 1 48 03 65 37; e-mail: [email protected]
Abstract
Purpose of review
The mechanisms implicated in the clinical manifestations of zonular diseases, especially ectopia lentis, are reviewed.
Recent findings
The molecular mechanisms involve fibrillin in a large spectrum of heritable diseases characterized by zonular stretching. The usual complications are refractive errors, especially myopia, glaucoma (either primary open angle, secondary angle closure and pupil block by anterior displacement of the lens) and retinal detachment.
Summary
The genetics and molecular understanding provide information for genetic counseling. Treatment of myopia and glaucoma depend on the underlying mechanism, and lens surgery techniques are continuously improved.
© 2008 Lippincott Williams & Wilkins, Inc.