The epidemic of type 1 diabetes: what is it telling us? : Current Opinion in Endocrinology, Diabetes and Obesity (original) (raw)

Diabetes and the endocrine pancreas II: Edited by Peter A. Gottlieb

what is it telling us?

aDepartment of Pediatrics

bBarbara Davis Center, University of Colorado, Aurora, Colorado, USA

Correspondence to Marian Rewers, MD, PhD, Barbara Davis Center for Childhood Diabetes, School of Medicine, University of Colorado Denver, Mail Stop A-140, 1775 Auora Ct, Aurora, CO 80045, USATel: +1 303 724 6757; fax: +1 303 724 6779; e-mail: [email protected]

Current Opinion in Endocrinology, Diabetes and Obesity 18(4):p 248-251, August 2011. | DOI: 10.1097/MED.0b013e32834872ce

Abstract

Purpose of review

Type 1 diabetes (T1D) is an autoimmune disorder which affects millions around the world. The incidence of T1D in children is increasing worldwide at a rate that cannot be explained by genetics alone. This review explores the recent research regarding possible causes of this epidemic.

Recent findings

Investigation into T1D epidemiology has recently focused on several hypotheses. These theories include the role of infections, early childhood diet, vitamin D exposure, environmental pollutants, increased height velocity, obesity, and insulin resistance in the risk for T1D. Over the past year, the evidence has strengthened for early childhood infections, dietary proteins, and insulin resistance as risk factors for T1D, but not for vitamin D exposure or environmental pollutants.

Summary

Investigation into the source of the current epidemic of T1D has shed light on several possible causes, but has not provided definitive answers, yet.