A Novel Reciprocal Chromosome Translocation... : The American Journal of Surgical Pathology (original) (raw)
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A Novel Reciprocal Chromosome Translocation t(11;22)(p13;q12) in an Intraabdominal Desmoplastic Small Round-Cell Tumor
Sawyer, Jeffrey R. Ph.D.; Tryka, A. Francine M.D.; Lewis, Jane M. M.D.
From the Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas. U.S.A.
Abstract
We report an intraabdominal desmoplastic small round-cell tumor that contains a novel reciprocal chromosome translocation t(11:22)(p13;q12). The tumor showed a reciprocal chromosome translocation which is different from the (11;22)(q24;q12) translocations seen in Ewing's and other small-cell tumors but affects the same breakpoint on chromosome 22(q12). This reciprocal chromosome translocation may prove to be a marker for intraabdominal desmoplastic small round-cell tumors.
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