Inhibition of protein kinase A activity during conditioned... : NeuroReport (original) (raw)
LEARNING AND MEMORY
Inhibition of protein kinase A activity during conditioned taste aversion retrieval: interference with extinction or reconsolidation of a memory?
Department of Psychology, Box 351525, University of Washington, Seattle, WA 98195-1525, USA
CACorresponding Author: [email protected]
Received 28 October 2002; accepted 9 January 2003
Abstract
The involvement of the cAMP-dependent protein kinase A (PKA) signaling pathway in protein synthesis-dependent memory consolidation has been supported by studies of fear conditioning and conditioned taste aversion (CTA). The present experiment examined whether inhibition of PKA activity at the time of memory retrieval impedes or promotes subsequent extinction. When Rp-cAMPS was infused into the amygdala at the time of CTA testing (retrieval), extinction was accelerated. Results confirm recent findings that stored memories become more labile when they are retrieved and extend these findings to CTA memories.
© 2003 Lippincott Williams & Wilkins, Inc.