The role of 15-lipoxygenase in atherogenesis: pro- and... : Current Opinion in Lipidology (original) (raw)
Genetics and Molecular Biology: PDF Only
The role of 15-lipoxygenase in atherogenesis: pro- and antiatherogenic actions
*Institute of Biochemistry, University Clinics Charité, Humboldt University, Berlin, Germany
†Baylor College of Medicine, Texas Medical Center, One Baylor Plaza, Houston
Abstract
Oxidative modification converts LDL to an atherogenic form and 15-lipoxygenase has been implicated in this process. Several lines of experimental evidence support such a proatherogenic action of the enzyme. However, recent data obtained with transgenic rabbits overexpressing 15-lipoxygenase suggest also an antiatherogenic effect. In this paper the pathophysiological relevance of 15-lipoxygenase in atherogenesis is critically reviewed.
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