Protective Effect of CCR2-64I and Not of CCR5-Δ32 and... : JAIDS Journal of Acquired Immune Deficiency Syndromes (original) (raw)
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Protective Effect of CCR2-64I and Not of CCR5-Δ32 and SDF1-3′A in Pediatric HIV-1 Infection
*Laboratorio de Biología Celular y Retrovirus, and †Servicio de Infectología, Hospital de Pediatría “J. P. Garrahan,” Buenos Aires, Argentina
Address correspondence and reprint requests to Luisa Sen, Laboratorio de Biología Celular y Retrovirus, Hospital de Pediatría “J. P. Garrahan,” Combate de Los Pozos 1881, 1245, Buenos Aires, Argentina; email: [email protected].
Manuscript received August 16, 1999; accepted November 17, 1999.
Abstract
Summary:
The effects of chemokine and chemokine receptor genetic polymorphisms such as stromal derived factor 1 (SDF1-3′A), CCR2-64I, and CCR5-Δ32 associated with HIV-1 transmission and/or rate of disease progression in infected study subjects remain highly controversial and have been analyzed primarily only in adults. We have investigated whether these polymorphisms may provide similar beneficial effects in children exposed to HIV-1 perinatally. The prevalence of CCR2-64I allele was significantly increased (p = .03) and the CCR2-64I genotype distribution was not in Hardy-Weinberg equilibrium, among HIV-1-exposed uninfected infants. Moreover, in the HIV-1-infected group, a delay to AIDS progression was observed among carriers of CCR2-64I allele. This is the first report that suggests a protective role of CCR2-64I allele in mother-to-infant HIV-1 transmission and documents a delay in disease progression, after the child has been infected with HIV-1. However, SDF1-3′A and CCR5-Δ32 alleles did not modify the rate of HIV-1 transmission or disease progression in HIV-1-infected children.
© 2000 Lippincott Williams & Wilkins, Inc.