Menopausal Symptoms and Treatment-Related Effects of... : Obstetrics & Gynecology (original) (raw)

Original Research

Barnabei, Vanessa M. MD, PhD; Cochrane, Barbara B. PhD, RN; Aragaki, Aaron K. MS; Nygaard, Ingrid MD; Williams, R Stan MD; McGovern, Peter G. MD; Young, Ronald L. MD; Wells, Ellen C. MD; O'Sullivan, Mary Jo MD; Chen, Bertha MD; Schenken, Robert MD; Johnson, Susan R. MD, MS for the Women's Health Initiative Investigators

*For a list of other members of the Women's Health Initiative Investigators, see Appendix.

This study was funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services. The active study drug and placebo were supplied by Wyeth-AyerstResearch Laboratories, Philadelphia, Pennsylvania.

Financial Disclosure Drs. Barnabei and Williams have received honoraria/consulting fees from Wyeth-Ayerst Research Laboratories within the past 3 years.

Address reprint requests to: Vanessa M. Barnabei, md, phd, Department of Obstetrics and Gynecology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226; e-mail: [email protected].

Received September 30, 2004. Received in revised form December 21, 2004. Accepted January 5, 2005.

OBJECTIVE:

To estimate the effects of estrogen plus progestin (E+P) therapy on menopausal symptoms, vaginal bleeding, gynecologic surgery rates, and treatment-related adverse effects in postmenopausal women.

METHODS:

Randomized, double-blind, placebo-controlled trial of 16,608 postmenopausal women, ages 50–79 (mean ± standard deviation 63.3 ± 7.1) years, with intact uterus, randomized to one tablet per day containing 0.625 mg conjugated equine estrogens plus 2.5 mg medroxyprogesterone acetate (n = 8,506) or placebo (n = 8,102), and followed for a mean of 5.6 years. Change in symptoms and treatment-related effects were analyzed at year 1 in all participants. Bleeding and gynecologic surgery rates were analyzed through study close-out.

RESULTS:

Baseline symptoms did not differ between the treatment groups. More women assigned to E+P than placebo reported relief of hot flushes (85.7% versus 57.7%, respectively; odds ratio 4.40; 95% confidence interval 3.40–5.71), night sweats (77.6% versus 57.4%; 2.58; 2.04–3.26), vaginal or genital dryness (74.1% versus 54.6%; 2.40; 1.90–3.02), joint pain or stiffness (47.1% versus 38.4%; 1.43; 1.24–1.64), and general aches or pains (49.3% versus 43.7%; 1.25; 1.08–1.44). Women asymptomatic at baseline who were assigned to E+P more often developed breast tenderness (9.3% versus 2.4%, respectively; 4.26; 3.59–5.04), vaginal or genital discharge (4.1% versus 1.0%; 4.47; 3.44–5.81), vaginal or genital irritation (4.2% versus 2.8%; 1.52; 1.27–1.81), and headaches (5.8% versus 4.7%; 1.26; 1.08–1.46) than women on placebo. Estrogen plus progestin treatment prevented the onset of new musculoskeletal symptoms. Vaginal bleeding was reported by 51% of women on E+P and 5% of women on placebo at 6 months; most bleeding was reported as spotting. Gynecologic surgeries (hysterectomy and dilation and curettage) were performed more frequently in women assigned to E+P (3.1% versus 2.5% for hysterectomy, hazard ratio = 1.23, P = .026; 5.4% versus 2.4% for dilation and curettage, hazard ratio = 2.23, P < .001).

CONCLUSION:

Estrogen plus progestin relieved some menopausal symptoms, such as vasomotor symptoms and vaginal or genital dryness, but contributed to treatment-related effects, such as bleeding, breast tenderness, and an increased likelihood of gynecologic surgery.

LEVEL OF EVIDENCE:

I

© 2005 The American College of Obstetricians and Gynecologists