Diabetes and cancer risk for all and specific sites among... : European Journal of Cancer Prevention (original) (raw)
Research papers: Environment
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-l Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan
Correspondence to Dr Kiyonori Kuriki, MSc, PhD, Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan
Tel: +81 52 762 6111; fax: +81 52 763 5233; e-mail: [email protected]
Received 11 August 2005 Accepted 6 February 2006
Abstract
Associations between diabetes and multisite cancer risk were examined in a case–control study of 11 672 incident cancer cases (5341 men and 6331 women) and 47 768 cancer-free controls (14 199 men and 33 569 women). Using an unconditional logistic regression model and controlling for potential confounding factors, a past/present history of diabetes was associated with cancer risks for all sites in both men and women (odds ratios=1.44 and 1.39, 95% confidence intervals=1.28–1.62 and 1.19–1.62), respectively. Significantly increased risk was found for cancers of the pharynx, esophagus, colorectum, liver, pancreas, larynx and lung among men, and of the stomach, liver, lung and cervix uteri among women. Among participants with a family history of diabetes, a past/present history of diabetes was also associated with cancer risks of all sites among men and women (odds ratios=1.41 and 1.96, 95% confidence intervals=1.04–1.93 and 1.44–2.68, respectively). The associations were highest for pancreatic cancer among men and the stomach, colorectum and corpus uteri among women. Our findings support the conclusion that diabetes is associated with the etiology of cancer development, and we suggest that a family history of diabetes should be considered as a risk factor for several cancer sites among participants with a past/present history of diabetes.
© 2007 Lippincott Williams & Wilkins, Inc.