Bedaquiline and Delamanid in Children With XDR... : The Pediatric Infectious Disease Journal (original) (raw)

Antimicrobial Reports

Bedaquiline and Delamanid in Children With XDR Tuberculosis: What is prolonged QTc?

From the Pediatric TB Clinic, Department of Pediatric Infectious Diseases, B J Wadia Hospital for Children, Mumbai, India.

Accepted for publication January 7, 2020.

The authors have no funding or conflicts of interest to disclose.

Address for correspondence: Ira Shah, MD, 1/B Saguna, 271/B St Francis Road, Vile Parle (W), Mumbai 400056, India. Email: [email protected].

Abstract

Bedaquiline and delamanid used to treat extensively drug-resistant tuberculosis are known to cause prolonged QTc. Two children with extensively drug-resistant tuberculosis were put on bedaquiline and delamanid and had prolonged QTc on the Bazett formula but normal QTc by the Fridericia formula. Both had no adverse effects. Correct formula for monitoring QTc should be used thereby preventing unnecessary withholding of medicines.