Molecular Mechanisms of Muscle Force Regulation: A Role for ... : Exercise and Sport Sciences Reviews (original) (raw)
Articles
A Role for Titin?
Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada
Address for correspondence: Walter Herzog, Ph.D., Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada, T2N 1N4, 2500 University Drive NW (E-mail: [email protected]).
Accepted for publication: August 2, 2011.
Associate Editor: Mark D. Grabiner, Ph.D., FACSM
Muscle contraction and force regulation is thought to occur exclusively through the interaction of the contractile proteins actin and myosin and in accordance with the assumptions underlying the cross-bridge theory. Here, we demonstrate that a third protein, titin, plays a major role in muscle force regulation, particularly for eccentric contractions and at long muscle and sarcomere lengths.
©2012 The American College of Sports Medicine