Alcohol consumption increases the incidence of... : European Journal of Gastroenterology & Hepatology (original) (raw)

Original Articles: Hepatology

Alcohol consumption increases the incidence of hepatocellular carcinoma in patients with hepatitis B cirrhosis but not in patients with hepatitis C cirrhosis

Departments of aGastroenterology

bGeneral surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China

Received 19 February 2020 Accepted 28 May 2020

Correspondence to Yan Li, PhD, 36 Sanhao Street, Heping District, Shenyang, Liaoning Province, 110004, China, Tel: +86 18940254944; fax: +86 24 96615 26111; e-mail: [email protected].

Abstract

Background

Liver cirrhosis and hepatocellular carcinoma (HCC) are common diseases in developing countries. HCC is a serious consequence of liver cirrhosis.

Methods

A total of 1095 decompensated hepatic cirrhotic patients admitted to our hospital were enrolled from September 2014 to August 2019. We described the components of cirrhotic etiology. We evaluated the impact of alcohol consumption on the incidence of HCC in patients with hepatitis B cirrhosis and hepatitis C cirrhosis.

Results

Among all cirrhotic patients admitted, the constituent ratios of hepatitis B cirrhosis and alcohol cirrhosis were 31.32% and 30.32%, respectively. The HCC incidence was higher in patients with hepatitis cirrhosis than in those with alcohol cirrhosis (24.2% in hepatitis B, 17.5% in hepatitis C and 3.92% in alcohol, P < 0.05). The HCC incidence in patients with concomitant hepatitis B virus (HBV) and alcohol consumption was higher than that in patients with HBV alone (33.70% vs. 20.72%, P < 0.05).

Conclusion

Hepatitis B and alcohol were major etiologies for cirrhotic patients. Alcohol consumption increased the incidence of HCC in patients with hepatitis B cirrhosis but not in patients with hepatitis C cirrhosis.