Heme oxygenase-1 polymorphism is not associated with riskof ... : European Journal of Gastroenterology & Hepatology (original) (raw)

Original articles

a Danish prospective study

Andersen, Vibekea; Christensen, Janeb; Overvad, Kimd; Tjønneland, Anneb; Vogel, Ullac,e

aMedical Department, Viborg Regional Hospital, Viborg

bDanish Cancer Society, Institute of Cancer Epidemiology

cNational Research Centre for the Working Environment, Copenhagen

dDepartment of Clinical Epidemiology, Aarhus University Hospital, Aalborg

eNational Food Institute, Technical University of Denmark, Soborg, Denmark

Correspondence to Vibeke Andersen, Medical Department, Viborg Regional Hospital, Heibergs Allé 4, Viborg DK-8800, Denmark Tel: +45 8927 2641; fax: +45 8927 3484; e-mail: [email protected]

Received August 5, 2010

Accepted October 12, 2010

European Journal of Gastroenterology & Hepatology 23(3):p 282-285, March 2011. | DOI: 10.1097/MEG.0b013e3283417f76

Abstract

Objective

Intake of red and processed meat confers risk of colorectal cancer (CRC). We wanted to test whether heme in meat promotes carcinogenesis.

Methods

Heme oxygenase-1 (HO-1, HMOX1) A-413T (rs2071746) was assessed in a nested case–cohort study of 383 CRC cases and 763 randomly selected participants from a prospective study of 57 053 individuals. Incidence rate ratios and 95% confidence intervals were calculated.

Results

No association was found between the HO-1 polymorphism and CRC (P value for trend for the fully adjusted estimates=0.29). No interaction with meat intake was found (P value for interaction=0.55).

Conclusion

The studied HO-1 polymorphism was not associated with risk of CRC suggesting that heme from meat is not important in CRC development.