Role of microRNAs in lymphoid biology and disease : Current Opinion in Hematology (original) (raw)
Lymphoid biology and diseases: Edited by Nancy Berliner
Department of Molecular Virology, Immunology and Medical Genetics, the Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA
Correspondence to Carlo M. Croce, 1082 Biomedical Research Tower, 460 West 12th Avenue, Columbus, OH 43210, USA Tel: +1 614 292 3063; fax: +1 614 292 3558; e-mail: [email protected]
Abstract
Purpose of review
This review provides a state-of-the-art knowledge on the implications of microRNA (miRNA) dysregulation in lymphoid malignancies.
Recent findings
Several new studies have broadened our understanding of how aberrations of the miRNome contribute to the development of a malignant lymphoid phenotype. Recently, a new pathogenetic model involving miRNAs and protein coding genes (such as TP53 and ZAP-70) has been identified and explains the prognostic implications of the most recurrent chromosomal abnormalities in human B-cell chronic lymphocytic leukemia. Moreover, new recent studies have addressed the role of miRNAs in human lymphomas and acute lymphoblastic leukemias.
Summary
The recent advances in our understanding of the role of miRNAs in lymphoid malignancies demonstrate that miRNAs can effectively be used as tumoral biomarkers with implications for diagnosis, prognosis, and prediction of response to therapy.
© 2011 Lippincott Williams & Wilkins, Inc.