The sinonasal bacterial microbiome in health and disease : Current Opinion in Otolaryngology & Head and Neck Surgery (original) (raw)
NOSE AND PARANASAL SINUSES: Edited by Samuel S. Becker and Nithin D. Adappa
aDepartment of Otolaryngology, University of Colorado School of Medicine
bDivision of Infectious Diseases
cUniversity of Colorado Microbiome Research Consortium, Aurora, Colorado, USA
Correspondence to Vijay R. Ramakrishnan, MD, Department of Otolaryngology, 12631 E 17th Ave, B205, Aurora, CO 80045, USA. Tel: +1 303 724 1950; fax: +1 303 724 1961; e-mail: [email protected]
Current Opinion in Otolaryngology & Head and Neck Surgery 24(1):p 20-25, February 2016. | DOI: 10.1097/MOO.0000000000000221
Abstract
Purpose of review
The development of culture-independent bacterial DNA sequencing techniques and integration into research practice has led to a burgeoning interest in the microbiome and its relevance to human health and disease. Introduction into the study of chronic rhinosinusitis in the past few years has shaped current thinking on the role of bacteria in the disease process.
Recent findings
Rich and diverse populations of bacteria inhabit the sinonasal cavity at all times. Decreased bacterial richness and diversity may be associated with disease state and outcomes.
Summary
Although there is much to be explored, the sinus microbiome appears to have potentially promising roles in many aspects of sinus health and disease.
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