Retrospective Analysis of Histopathologic Prognostic... : The Cancer Journal (original) (raw)

Special Issue on Management of Peritoneal Carcinomatosis From Colorectal and Appendiceal Malignancy: Original Article

Retrospective Analysis of Histopathologic Prognostic Factors After Hepatectomy for Intrahepatic Cholangiocarcinoma

Jiang, Bei-Ge MD*; Sun, Liang-Liang MD†; Yu, Wen-Long MD*; Tang, Zhao-Hui MD*; Zong, Ming MD*; Zhang, Yong-Jie MD*

From the *Eastern Hepatobiliary Surgery Hospital, Second Military Medical University; and †Department of Endocrinology and Metabolism, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.

Bei-Ge Jiang and Liang-Liang Sun are the first authors.

Reprints: Ming Zong or Yong-jie Zhang, Department of Laparoscopy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, People's Republic of China. E-mail: [email protected].

Abstract

Background:

The aim of this study was to investigate histopathologic prognostic factors in patients with intrahepatic cholangiocarcinoma (ICC) whose tumors were resected to determine the optimal surgical strategies.

Methods:

One hundred and two ICC patients who underwent laparotomy from July 1998 to December 2000 were followed up successfully. Histopathologic variables were selected for univariate and multivariate analyses to evaluate their influence on the outcome.

Results:

The 1-, 3-, and 5-year survival rates after surgery were 56.9%, 25.5%, and 16.9%, respectively. The average survival duration was 21.91 ± 20.17 months. In univariate analysis, the presence of lymph node (LN) metastasis, number of LNs with metastases, presence of intrahepatic metastasis, curative resection, and TNM stage were significant risk factors for survival. Multivariate analysis revealed that intrahepatic metastasis, noncurative resection, and TNM stage IVa were independent prognostic factors.

Conclusions:

The histopathologic characteristics of intrahepatic metastasis were closely related to poor prognosis in ICC patients. Extensive hepatectomy with LN dissection may offer the only chance for long-term survival in patients with ICC.