Host Defence Mechanisms Against Japanese Encephalitis Virus Infection in Mice (original) (raw)

• _info_Info
  • Article information
  • Full-Text
  • Figures and Tables
  • References (27)
  • Cited By (54)
  • Supplementary Material
  • Metrics
• _list_Sections

Abstract

SUMMARY

The role of antibody and cell-mediated immunity in the resistance to Japanese encephalitis virus (JEV) infection was studied in adult mice. Passively transferred antibodies obtained up to 2 weeks after primary infection protected the recipient mice against a challenge infection with JEV. Antibody obtained at 4 or 5 weeks failed to protect despite the presence of high titres of neutralizing antibody. Protection was abrogated by pretreatment of the early serum with 2-mercaptoethanol to remove IgM. Similarly, adoptive transfer of immune spleen cells obtained up to 2 weeks after immunization provided protection. The protective effect was abolished by pretreatment of the immune spleen cells with anti-Thy 1.2 antiserum and complement. These findings suggest a role of T lymphocytes and IgM antibody in recovery from JEV infection.

• Received: 20/04/1982
• Accepted:29/11/1982
• Published Online:01/04/1983

© Journal of General Virology 1983

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-64-4-805

1983-04-01

2025-01-17

Full text loading...

Most read this month

Article

content/journal/jgv

Journal

5

3

false

en