Genetic and antigenic characterization of an atypical pestivirus isolate, a putative member of a novel pestivirus species (original) (raw)
Abstract
The genus Pestivirus within the family Flaviviridae currently consists of four different main species: Classical swine fever virus, Bovine viral diarrhea virus types 1 and 2 and Border disease virus. A fifth tentative species is represented by an isolate from a giraffe. In this study, a completely new pestivirus, isolated from a batch of fetal calf serum that was collected in Brazil, is described. It is proposed that the isolate D32/00_‘HoBi’ may constitute a novel sixth pestivirus species, because it is genetically, as well as antigenically, markedly different from all other pestiviruses. Based on the entire Npro- and E2-encoding sequences, identities of <70 % to all other pestivirus species were determined. Similarly, cross-neutralization and binding studies using antisera and mAbs revealed marked antigenic differences between D32/00_‘HoBi’ and all other pestiviruses.
- Received: 28/04/2004
- Accepted:25/08/2004
- Published Online:01/12/2004
SGM
Article metrics loading...
/content/journal/jgv/10.1099/vir.0.80238-0
2004-12-01
2024-10-23
Full text loading...
/deliver/fulltext/jgv/85/12/vir853647.html?itemId=/content/journal/jgv/10.1099/vir.0.80238-0&mimeType=html&fmt=ahah
Most read this month
Article
content/journal/jgv
Journal
5
3
false
en